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- W2036348522 abstract "Changes in the potential and contractility of smooth muscle cells of guinea-pig taenia caeci were measured (22°C) in order to investigate the effect of mebeverine, a derivative of β-phenylethylamine, on α1-receptor-operated ion channels in particular. Mebeverine (6×10−6 M showed atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. Hyperpolarization and cessation of spike activity of the muscle cells, accompanied by an increase amplitude of the electronic potential were observed in the presence of mebeverine (6 × 10−5) after block of the α2-, β- and muscarinic receptors. This effect of mebeverine was not observed in low-sodium solution (23.8 mM), suggesting that mebeverine decreased sodium permeability. The α1-receptor-induced hyperpolarization caused by adrenaline (3 × 10−6 M) in the presence of mebeverine declined after reaching an initial maximum. The hyperpolarization induced by a second addition of adrenaline to the preparation was decreased and sustained in the presence of mebeverine, while the decrease of the electronic potential evoked during the α1 response was less pronounced. The transient hyperpolarization representing the α1 response in the absence of extracellular calcium developed more slowly in the presence of mebeverine, the area of the response being constant. When the experiment was continued in calcium-free solution after a short exposure to calcium-containing Krebs solution still in the presence of mebeverine, the α1-receptor-induced hyperpolarization was suppressed. Depolarization of the muscle cells was observed on addition of adrenaline to the preparation in calcium-free conditions and in the presence of apamin (3 × 10−7 M). Mebeverine affected this reversed α1 response similarly to the hyperpolarization observed without apamin. The results show that mebeverine inhibited the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci." @default.
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- W2036348522 date "1990-07-01" @default.
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- W2036348522 title "Effect of cytochalasin B on isolated smooth muscle cells from guinea-pig taenia caeci" @default.
- W2036348522 doi "https://doi.org/10.1016/0014-2999(90)93999-7" @default.
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