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• W2036353500 abstract "We have investigated the suppressive effect of human natural killer (NK) cells on autologous B-cell proliferation. Removal of NK cells by anti-NK-cell monoclonal antibodies (CD16, Leu 11b; Leu 7) increased by 2-3-fold the proliferative response of purified B cells activated by anti-mu and B-cell growth factor (BCGF). The inhibitory effect of NK cells was observed using recombinant IL-2 or semi-purified BCGF-I as sources of BCGF. Moreover NK cells, highly purified by centrifugation on a Percoll discontinuous density gradient, suppressed the proliferative response of purified autologous B cells activated by anti-mu and BCGF. These results show a suppressive effect of human NK cells on B-cell proliferation in vitro." @default.
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• W2036353500 date "1990-03-01" @default.
• W2036353500 modified "2023-10-16" @default.
• W2036353500 title "Human natural killer cells suppress the proliferation of B cells" @default.
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• W2036353500 doi "https://doi.org/10.1016/0165-2478(90)90036-p" @default.
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