Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036378796> ?p ?o ?g. }
- W2036378796 endingPage "844" @default.
- W2036378796 startingPage "834" @default.
- W2036378796 abstract "The mechanisms that maintain human T cell memory during normal and perturbed homeostasis are not fully understood. The repeated induction of profound lymphocytopenia in patients undergoing multiple cycles of cytotoxic chemotherapy infrequently results in severe infections with viruses controlled by memory T cells, suggesting that some memory T cells survive chemotherapy and restore immunity. Here, we identified a distinct subpopulation of memory CD8+ T cells with the ability to rapidly efflux and survive exposure to chemotherapy drugs in vitro and in vivo. T cells with high efflux capacity shared expression of molecules with hematopoietic stem cells, were quiescent in nonlymphocytopenic individuals, and were induced to proliferate in patients rendered lymphocytopenic after chemotherapy. Effluxing T cells differentiated into noneffluxing subsets in response to antigen stimulation and inflammatory signals, thereby contributing to repopulation of memory cells after chemotherapy." @default.
- W2036378796 created "2016-06-24" @default.
- W2036378796 creator A5010246469 @default.
- W2036378796 creator A5057920623 @default.
- W2036378796 creator A5072451390 @default.
- W2036378796 creator A5087281332 @default.
- W2036378796 creator A5089990813 @default.
- W2036378796 date "2009-11-01" @default.
- W2036378796 modified "2023-10-15" @default.
- W2036378796 title "A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy" @default.
- W2036378796 cites W1481612531 @default.
- W2036378796 cites W1511076147 @default.
- W2036378796 cites W1601504908 @default.
- W2036378796 cites W1613950543 @default.
- W2036378796 cites W1869322032 @default.
- W2036378796 cites W1904297401 @default.
- W2036378796 cites W1905121951 @default.
- W2036378796 cites W1974208182 @default.
- W2036378796 cites W1976460197 @default.
- W2036378796 cites W1977189837 @default.
- W2036378796 cites W1979565071 @default.
- W2036378796 cites W1979787704 @default.
- W2036378796 cites W1981480494 @default.
- W2036378796 cites W2001749720 @default.
- W2036378796 cites W2006027051 @default.
- W2036378796 cites W2006434892 @default.
- W2036378796 cites W2014330546 @default.
- W2036378796 cites W2024911372 @default.
- W2036378796 cites W2029517572 @default.
- W2036378796 cites W2065026092 @default.
- W2036378796 cites W2069340283 @default.
- W2036378796 cites W2070212505 @default.
- W2036378796 cites W2071548401 @default.
- W2036378796 cites W2102264469 @default.
- W2036378796 cites W2107182575 @default.
- W2036378796 cites W2112998733 @default.
- W2036378796 cites W2124373740 @default.
- W2036378796 cites W2129860342 @default.
- W2036378796 cites W2138993111 @default.
- W2036378796 cites W2141863692 @default.
- W2036378796 cites W2158810411 @default.
- W2036378796 cites W2165112338 @default.
- W2036378796 cites W2168443986 @default.
- W2036378796 cites W2168951760 @default.
- W2036378796 cites W2315098267 @default.
- W2036378796 cites W2512454832 @default.
- W2036378796 cites W2592935721 @default.
- W2036378796 cites W4239564692 @default.
- W2036378796 cites W4362218353 @default.
- W2036378796 doi "https://doi.org/10.1016/j.immuni.2009.09.015" @default.
- W2036378796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2789980" @default.
- W2036378796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19879163" @default.
- W2036378796 hasPublicationYear "2009" @default.
- W2036378796 type Work @default.
- W2036378796 sameAs 2036378796 @default.
- W2036378796 citedByCount "157" @default.
- W2036378796 countsByYear W20363787962012 @default.
- W2036378796 countsByYear W20363787962013 @default.
- W2036378796 countsByYear W20363787962014 @default.
- W2036378796 countsByYear W20363787962015 @default.
- W2036378796 countsByYear W20363787962016 @default.
- W2036378796 countsByYear W20363787962017 @default.
- W2036378796 countsByYear W20363787962018 @default.
- W2036378796 countsByYear W20363787962019 @default.
- W2036378796 countsByYear W20363787962020 @default.
- W2036378796 countsByYear W20363787962021 @default.
- W2036378796 countsByYear W20363787962022 @default.
- W2036378796 countsByYear W20363787962023 @default.
- W2036378796 crossrefType "journal-article" @default.
- W2036378796 hasAuthorship W2036378796A5010246469 @default.
- W2036378796 hasAuthorship W2036378796A5057920623 @default.
- W2036378796 hasAuthorship W2036378796A5072451390 @default.
- W2036378796 hasAuthorship W2036378796A5087281332 @default.
- W2036378796 hasAuthorship W2036378796A5089990813 @default.
- W2036378796 hasBestOaLocation W20363787961 @default.
- W2036378796 hasConcept C109159458 @default.
- W2036378796 hasConcept C154317977 @default.
- W2036378796 hasConcept C167672396 @default.
- W2036378796 hasConcept C202751555 @default.
- W2036378796 hasConcept C203014093 @default.
- W2036378796 hasConcept C207001950 @default.
- W2036378796 hasConcept C2776694085 @default.
- W2036378796 hasConcept C28328180 @default.
- W2036378796 hasConcept C502942594 @default.
- W2036378796 hasConcept C54355233 @default.
- W2036378796 hasConcept C86803240 @default.
- W2036378796 hasConcept C8891405 @default.
- W2036378796 hasConcept C95444343 @default.
- W2036378796 hasConceptScore W2036378796C109159458 @default.
- W2036378796 hasConceptScore W2036378796C154317977 @default.
- W2036378796 hasConceptScore W2036378796C167672396 @default.
- W2036378796 hasConceptScore W2036378796C202751555 @default.
- W2036378796 hasConceptScore W2036378796C203014093 @default.
- W2036378796 hasConceptScore W2036378796C207001950 @default.
- W2036378796 hasConceptScore W2036378796C2776694085 @default.
- W2036378796 hasConceptScore W2036378796C28328180 @default.
- W2036378796 hasConceptScore W2036378796C502942594 @default.
- W2036378796 hasConceptScore W2036378796C54355233 @default.