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- W2036381361 abstract "A sensitive system for the study of the mechanism of action 2-mercaptoethanol in stimulating of mouse spleen cell cultures is described. In this system the triggering of stimulation of cells by a mitogen or antigen was dependent on the presence of 2-mercaptoethanol (2-ME) in the medium. To obtain a similar stimulatory effect, 2-ME could be replaced by L-cystine or L-cysteine in the presence or absence of a mitogen. In the presence of a mitogen and below the saturation level, cystine was more effective than cysteine. By increasing in this system, the cystine concentration, to the double of that of the basal medium, a strong stimulation of cells was produced. Conversely, in the absence of mitogen, cysteine was significantly more effective than cystine. Addition of 2-ME led to an increased entry of [14C]L-cystine into the TCA-soluble pool of cells while the thiol had no influence on the uptake of a mixture of different amino acids. We conclude that in this system the role of 2-ME is to enable the utilization of otherwise ineffectively low concentrations of cystine by enhancing the entry of this amino acid into the amino acid pool of the cells." @default.
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- W2036381361 title "The role of 2-mercaptoethanol in the stimulation of spleen cell cultures: Increased uptake of cystine into the TCA-soluble pool" @default.
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- W2036381361 doi "https://doi.org/10.1016/0165-2478(82)90013-x" @default.
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