FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036402910> ?p ?o ?g. }

• W2036402910 endingPage "291" @default.
• W2036402910 startingPage "291" @default.
• W2036402910 abstract "Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin." @default.
• W2036402910 created "2016-06-24" @default.
• W2036402910 creator A5003507095 @default.
• W2036402910 creator A5015305100 @default.
• W2036402910 creator A5019499777 @default.
• W2036402910 creator A5028728603 @default.
• W2036402910 creator A5037177252 @default.
• W2036402910 creator A5060761933 @default.
• W2036402910 creator A5062991231 @default.
• W2036402910 creator A5063439320 @default.
• W2036402910 creator A5064866127 @default.
• W2036402910 creator A5076771471 @default.
• W2036402910 date "2013-01-01" @default.
• W2036402910 modified "2023-09-28" @default.
• W2036402910 title "Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells" @default.
• W2036402910 cites W1258584912 @default.
• W2036402910 cites W1573743827 @default.
• W2036402910 cites W1963890387 @default.
• W2036402910 cites W1968075505 @default.
• W2036402910 cites W1981232450 @default.
• W2036402910 cites W1982397837 @default.
• W2036402910 cites W1984475127 @default.
• W2036402910 cites W1997576503 @default.
• W2036402910 cites W1997889012 @default.
• W2036402910 cites W2010851299 @default.
• W2036402910 cites W2021824240 @default.
• W2036402910 cites W2028162650 @default.
• W2036402910 cites W2035188342 @default.
• W2036402910 cites W2035652406 @default.
• W2036402910 cites W2041811166 @default.
• W2036402910 cites W2042484101 @default.
• W2036402910 cites W2060798006 @default.
• W2036402910 cites W2064703543 @default.
• W2036402910 cites W2065195919 @default.
• W2036402910 cites W2069796573 @default.
• W2036402910 cites W2069845811 @default.
• W2036402910 cites W2074412378 @default.
• W2036402910 cites W2094192074 @default.
• W2036402910 cites W2096371557 @default.
• W2036402910 cites W2101063496 @default.
• W2036402910 cites W2102379101 @default.
• W2036402910 cites W2105666596 @default.
• W2036402910 cites W2108491241 @default.
• W2036402910 cites W2146977720 @default.
• W2036402910 cites W2153558905 @default.
• W2036402910 cites W2419269917 @default.
• W2036402910 doi "https://doi.org/10.4196/kjpp.2013.17.4.291" @default.
• W2036402910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3741485" @default.
• W2036402910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23946688" @default.
• W2036402910 hasPublicationYear "2013" @default.
• W2036402910 type Work @default.
• W2036402910 sameAs 2036402910 @default.
• W2036402910 citedByCount "18" @default.
• W2036402910 countsByYear W20364029102013 @default.
• W2036402910 countsByYear W20364029102014 @default.
• W2036402910 countsByYear W20364029102015 @default.
• W2036402910 countsByYear W20364029102016 @default.
• W2036402910 countsByYear W20364029102017 @default.
• W2036402910 countsByYear W20364029102019 @default.
• W2036402910 countsByYear W20364029102020 @default.
• W2036402910 countsByYear W20364029102021 @default.
• W2036402910 countsByYear W20364029102022 @default.
• W2036402910 countsByYear W20364029102023 @default.
• W2036402910 crossrefType "journal-article" @default.
• W2036402910 hasAuthorship W2036402910A5003507095 @default.
• W2036402910 hasAuthorship W2036402910A5015305100 @default.
• W2036402910 hasAuthorship W2036402910A5019499777 @default.
• W2036402910 hasAuthorship W2036402910A5028728603 @default.
• W2036402910 hasAuthorship W2036402910A5037177252 @default.
• W2036402910 hasAuthorship W2036402910A5060761933 @default.
• W2036402910 hasAuthorship W2036402910A5062991231 @default.
• W2036402910 hasAuthorship W2036402910A5063439320 @default.
• W2036402910 hasAuthorship W2036402910A5064866127 @default.
• W2036402910 hasAuthorship W2036402910A5076771471 @default.
• W2036402910 hasBestOaLocation W20364029101 @default.
• W2036402910 hasConcept C101762097 @default.
• W2036402910 hasConcept C104317684 @default.
• W2036402910 hasConcept C121608353 @default.
• W2036402910 hasConcept C127561419 @default.
• W2036402910 hasConcept C134320426 @default.
• W2036402910 hasConcept C143065580 @default.
• W2036402910 hasConcept C150194340 @default.
• W2036402910 hasConcept C153911025 @default.
• W2036402910 hasConcept C161879069 @default.
• W2036402910 hasConcept C173396325 @default.
• W2036402910 hasConcept C185592680 @default.
• W2036402910 hasConcept C190283241 @default.
• W2036402910 hasConcept C22615655 @default.
• W2036402910 hasConcept C2778250585 @default.
• W2036402910 hasConcept C2780110267 @default.
• W2036402910 hasConcept C502942594 @default.
• W2036402910 hasConcept C530470458 @default.
• W2036402910 hasConcept C54009773 @default.
• W2036402910 hasConcept C54355233 @default.
• W2036402910 hasConcept C55493867 @default.
• W2036402910 hasConcept C62478195 @default.
• W2036402910 hasConcept C86339819 @default.
• W2036402910 hasConcept C86803240 @default.

• next