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• W2036403425 endingPage "10" @default.
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• W2036403425 abstract "Transcription factor Histone Nuclear Factor P (HiNF-P; gene symbol Hinfp) mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin. The HiNF-P/p220NPAT complex controls multiple H4 genes in established human cell lines and is critical for cell proliferation. The mouse HinfpLacZ null allele causes early embryonic lethality due to a blastocyst defect. However, neither Hinfp function nor its temporal expression relative to histone H4 genes during fetal development has been explored. Here, we establish that expression of Hinfp is biologically coupled with expression of twelve functional mouse H4 genes during pre- and post-natal tissue-development. Both Hinfp and H4 genes are robustly expressed at multiple embryonic (E) days (from E5.5 to E15.5), coincident with ubiquitous LacZ staining driven by the Hinfp promoter. Five highly expressed mouse H4 genes (Hist1h4d, Histh4f, Hist1h4m and Hist2h4) account for > 90% of total histone H4 mRNA throughout development. Post-natal expression of H4 genes in mice is most evident in lung, spleen, thymus and intestine, and with few exceptions (e.g., adult liver) correlates with Hinfp gene expression. Histone H4 gene expression decreases but Hinfp levels remain constitutive upon cell growth inhibition in culture. The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development." @default.
• W2036403425 created "2016-06-24" @default.
• W2036403425 creator A5008755139 @default.
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• W2036403425 date "2011-09-01" @default.
• W2036403425 modified "2023-10-11" @default.
• W2036403425 title "Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development" @default.
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• W2036403425 doi "https://doi.org/10.1016/j.gene.2011.05.002" @default.
• W2036403425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164518" @default.
• W2036403425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21605641" @default.
• W2036403425 hasPublicationYear "2011" @default.
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