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- W2036406056 abstract "In Reply.— The statement in the above-referenced editorial that DNCB depletes the of glutathione in rat skin, thus blocking an important detoxification system of mammalian cells was indeed incorrect. In fact, activity of glutathione S-transferase should read content of glutathione. Undoubtedly, the Ames test is a relatively quick and inexpensive test, which is preferentially designed to sensitively detect point mutations inSalmonella typhimurium. The correlation between carcinogenic potency and mutagenic potency in the Ames test is promising; the overlap between the detections of mutagenicity and carcinogenicity of more than 1,000 compounds was 70% to 80%.1-3However, the routinely performed assay is suitable neither for direct extrapolation to humans nor for quantitative risk assessment.4 Also, if one considers the positive results of DCNB in the Ames test and the mammalian cell transformation assay as just a first step, these findings cannot to ignored." @default.
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- W2036406056 date "1986-01-01" @default.
- W2036406056 modified "2023-09-25" @default.
- W2036406056 title "Potential Hazards of Dinitrochlorobenzene (DNCB) Disputed-Reply" @default.
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- W2036406056 doi "https://doi.org/10.1001/archderm.1986.01660130013002" @default.
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