Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036408070> ?p ?o ?g. }
- W2036408070 endingPage "5797" @default.
- W2036408070 startingPage "5789" @default.
- W2036408070 abstract "Cell-to-cell spread of human immunodeficiency virus (HIV-1) between immune cells was first observed over 20 years ago. During this time, the question of whether this infection route favours viral evasion of neutralizing antibodies (NAbs) targeting the virus envelope glycoprotein (Env) has been repeatedly investigated, but with conflicting results. A clearer picture has formed in the last few years as more broadly neutralizing antibodies have been isolated and we gain further insight into the mechanisms of HIV-1 transmission at virological and infectious synapses. Nevertheless consensus is still lacking, a situation which may be at least partly explained by variability in the experimental approaches used to study the activity of NAbs in the cell-to-cell context. In this review we focus on the most critical question concerning the activity of NAbs against cell-to-cell transmission: is NAb inhibition of cell-to-cell HIV-1 quantitatively or qualitatively different from cell-free infection? Overall, data consistently show that NAbs are capable of blocking HIV-1 infection at synapses, supporting the concept that cell-to-cell infection occurs through directed transfer of virions accessible to the external environment. However, more recent findings suggest that higher concentrations of certain NAbs might be needed to inhibit synaptic infection, with important potential implications for prophylactic vaccine development. We discuss several mechanistic explanations for this relative and selective loss of activity, and highlight gaps in knowledge that are still to be explored." @default.
- W2036408070 created "2016-06-24" @default.
- W2036408070 creator A5048598611 @default.
- W2036408070 creator A5071199689 @default.
- W2036408070 creator A5077123406 @default.
- W2036408070 date "2013-12-01" @default.
- W2036408070 modified "2023-10-02" @default.
- W2036408070 title "Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies" @default.
- W2036408070 cites W1496030143 @default.
- W2036408070 cites W1509894959 @default.
- W2036408070 cites W1963807652 @default.
- W2036408070 cites W1964093787 @default.
- W2036408070 cites W1965266980 @default.
- W2036408070 cites W1967398944 @default.
- W2036408070 cites W1968754461 @default.
- W2036408070 cites W1972341594 @default.
- W2036408070 cites W1977389533 @default.
- W2036408070 cites W1977929936 @default.
- W2036408070 cites W1983262897 @default.
- W2036408070 cites W1986290362 @default.
- W2036408070 cites W1988140844 @default.
- W2036408070 cites W1991112092 @default.
- W2036408070 cites W1991187231 @default.
- W2036408070 cites W1992366636 @default.
- W2036408070 cites W1992566288 @default.
- W2036408070 cites W1992888167 @default.
- W2036408070 cites W1995466180 @default.
- W2036408070 cites W1996011751 @default.
- W2036408070 cites W1996061504 @default.
- W2036408070 cites W1996684522 @default.
- W2036408070 cites W1996939435 @default.
- W2036408070 cites W2000564337 @default.
- W2036408070 cites W2006483986 @default.
- W2036408070 cites W2009671611 @default.
- W2036408070 cites W2009898112 @default.
- W2036408070 cites W2016180326 @default.
- W2036408070 cites W2020422739 @default.
- W2036408070 cites W2023604714 @default.
- W2036408070 cites W2024287923 @default.
- W2036408070 cites W2028834214 @default.
- W2036408070 cites W2029135056 @default.
- W2036408070 cites W2030541908 @default.
- W2036408070 cites W2033645653 @default.
- W2036408070 cites W2034028541 @default.
- W2036408070 cites W2034996626 @default.
- W2036408070 cites W2035871823 @default.
- W2036408070 cites W2038154446 @default.
- W2036408070 cites W2039028257 @default.
- W2036408070 cites W2043152270 @default.
- W2036408070 cites W2050070282 @default.
- W2036408070 cites W2058740164 @default.
- W2036408070 cites W2062011023 @default.
- W2036408070 cites W2062204035 @default.
- W2036408070 cites W2063789804 @default.
- W2036408070 cites W2063825303 @default.
- W2036408070 cites W2065329551 @default.
- W2036408070 cites W2065794926 @default.
- W2036408070 cites W2067455871 @default.
- W2036408070 cites W2069818169 @default.
- W2036408070 cites W2069981708 @default.
- W2036408070 cites W2070086938 @default.
- W2036408070 cites W2070209049 @default.
- W2036408070 cites W2070601460 @default.
- W2036408070 cites W2072974935 @default.
- W2036408070 cites W2075864449 @default.
- W2036408070 cites W2075934385 @default.
- W2036408070 cites W2076225670 @default.
- W2036408070 cites W2078489697 @default.
- W2036408070 cites W2080089116 @default.
- W2036408070 cites W2081313987 @default.
- W2036408070 cites W2082091832 @default.
- W2036408070 cites W2083726777 @default.
- W2036408070 cites W2083889661 @default.
- W2036408070 cites W2085782638 @default.
- W2036408070 cites W2089692155 @default.
- W2036408070 cites W2090763940 @default.
- W2036408070 cites W2095703604 @default.
- W2036408070 cites W2096387523 @default.
- W2036408070 cites W2097386513 @default.
- W2036408070 cites W2097912258 @default.
- W2036408070 cites W2098615501 @default.
- W2036408070 cites W2098781795 @default.
- W2036408070 cites W2100298806 @default.
- W2036408070 cites W2100825958 @default.
- W2036408070 cites W2103712192 @default.
- W2036408070 cites W2104802051 @default.
- W2036408070 cites W2109425369 @default.
- W2036408070 cites W2109590624 @default.
- W2036408070 cites W2110780972 @default.
- W2036408070 cites W2113236498 @default.
- W2036408070 cites W2116076032 @default.
- W2036408070 cites W2118820599 @default.
- W2036408070 cites W2122617162 @default.
- W2036408070 cites W2128579789 @default.
- W2036408070 cites W2131332541 @default.
- W2036408070 cites W2131903471 @default.
- W2036408070 cites W2131981029 @default.
- W2036408070 cites W2132629607 @default.