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• W2036408094 abstract "Ring size reduction of the central piperidine ring of lobelane yielded pyrrolidine analogues that showed marked inconsistencies in their ability to bind to the dihydrotetrabenazine (DTBZ) binding site on the vesicular monoamine transporter-2 (VMAT2) and their ability to inhibit VMAT2 function. The structure-activity relationships indicate that structural modification within the pyrrolidine series resulted in analogues that interact with two different sites, i.e., the DTBZ binding site and an alternative site on VMAT2 to inhibit transporter function." @default.
• W2036408094 created "2016-06-24" @default.
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• W2036408094 date "2009-08-19" @default.
• W2036408094 modified "2023-09-24" @default.
• W2036408094 title "Pyrrolidine Analogues of Lobelane: Relationship of Affinity for the Dihydrotetrabenazine Binding Site with Function of the Vesicular Monoamine Transporter 2 (VMAT2)" @default.
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• W2036408094 doi "https://doi.org/10.1021/jm900770h" @default.
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