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• W2036419275 abstract "The effect of systemic naloxone on the activity evoked by C-fibre stimulation in dorsal horn neurones of the rat spinal cord has been investigated. Recordings were made in unanaesthetized, decerebrate spinalized rats. Fifteen units were recorded from laminae 4 and 5 of the dorsal horn, 11 of these units were excited by naloxone (0.2–1.0 mg/kg). The onset of this excitation was after 20 sec to 5 min and recovery to control levels occurred within 15–40 min. Of 17 units recorded in substantia gelatinosa of the dorsal horn, 13 were inhibited by the naloxone. The latency of onset of this inhibition was short (2–10 sec) and the effect persisted for 5–10 min. The effects were largely restricted to C-fibre evoked activity although sometimes Aδ responses were similarly altered. Neurones stimulated at Aβ-fibre threshold, or whose sole afferent input were Aβ-fibres, were unaffected by the naloxone. The stereoisomer of naloxone, (+)naloxone which is inactive in opiate receptor binding tests, failed to produce the same changes found with (−)naloxone in 17 units. These results show a differential effect of naloxone on neurones in the dorsal horn which respond to C-fibre input. Units in the substantia gelatinosa are inhibited while units in deeper laminae are excited by naloxone. These effects are likely to be mediated by the blockade of endogenous opioids in the spinal cord." @default.
• W2036419275 created "2016-06-24" @default.
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• W2036419275 date "1980-12-01" @default.
• W2036419275 modified "2023-10-17" @default.
• W2036419275 title "The stereospecific effect of naloxone on rat dorsal horn neurones; Inhibition in superficial laminae and excitation in deeper laminae" @default.
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• W2036419275 doi "https://doi.org/10.1016/0304-3959(80)90044-5" @default.
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