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• W2036419595 abstract "For the past two decades much research on selective photothermolysis of port wine stain vasculature has been devoted to optimizing laser parameters. Unfortunately, 60% of patients still respond suboptimally to laser therapy, despite significant innovations in treatment strategies and laser technology. Here we present a novel treatment approach based on combining selective photothermolysis with the administration of prothrombotic and/or anti-fibrinolytic pharmaceutical agents, with the aim of enhancing vaso-occlusion and post-treatment remodelling in difficult-to-target vessels. A hypercoagulable state of blood will instill laser-induced occlusive thrombosis in a wider array of vessel diameters at greater dermal depths, whereby larger vascular segments will ultimately undergo the chronic inflammatory processes that result in blood volume reduction, and thus lesional blanching. With thrombosis as a primary trigger for these inflammatory processes, we have extrapolated the threshold damage profile that is required for clinically relevant thrombus formation. Consequently, a recently proposed model of thrombus organization, in which recanalization is associated with endothelial progenitor cell-mediated neovasculogenesis, is elaborated in the framework of lesional blanching and juxtaposed to angiogenic reconstruction of affected dermal vasculature. Since neovasculogenesis and angiogenesis are regulated by the degree of vaso-occlusion and corollary drop in local oxygen tension, both can be manipulated by the administration of procoagulant pharmaceuticals. Lastly, in an effort to optimally balance selective photothermolysis with pharmacokinetics and clinical safety, the use of a gold nanoshell drug delivery system, in which the procoagulant drugs are encapsulated by a wavelength-modulated, gold-coated polymer matrix, is proposed. We have termed this modality site-specific pharmaco-laser therapy." @default.
• W2036419595 created "2016-06-24" @default.
• W2036419595 creator A5043837012 @default.
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• W2036419595 creator A5078662879 @default.
• W2036419595 creator A5078824354 @default.
• W2036419595 date "2005-01-01" @default.
• W2036419595 modified "2023-10-15" @default.
• W2036419595 title "Towards optimization of selective photothermolysis: prothrombotic pharmaceutical agents as potential adjuvants in laser treatment of port wine stains" @default.
• W2036419595 cites W1270092359 @default.
• W2036419595 cites W130104401 @default.
• W2036419595 cites W1485875137 @default.
• W2036419595 cites W1494296538 @default.
• W2036419595 cites W1502896205 @default.
• W2036419595 cites W1503551456 @default.
• W2036419595 cites W1516806117 @default.
• W2036419595 cites W153840473 @default.
• W2036419595 cites W1569560733 @default.
• W2036419595 cites W1586474677 @default.
• W2036419595 cites W1596458865 @default.
• W2036419595 cites W1600542667 @default.
• W2036419595 cites W1653001760 @default.
• W2036419595 cites W1811402656 @default.
• W2036419595 cites W182898904 @default.
• W2036419595 cites W1880636970 @default.
• W2036419595 cites W1895289679 @default.
• W2036419595 cites W1939015906 @default.
• W2036419595 cites W1964184286 @default.
• W2036419595 cites W1965248413 @default.
• W2036419595 cites W1965621232 @default.
• W2036419595 cites W1966441345 @default.
• W2036419595 cites W1967665698 @default.
• W2036419595 cites W1968470511 @default.
• W2036419595 cites W1968493525 @default.
• W2036419595 cites W1968847928 @default.
• W2036419595 cites W1969713456 @default.
• W2036419595 cites W1970590929 @default.
• W2036419595 cites W1970959706 @default.
• W2036419595 cites W1973116562 @default.
• W2036419595 cites W1973631902 @default.
• W2036419595 cites W1974812650 @default.
• W2036419595 cites W1977385644 @default.
• W2036419595 cites W1977532338 @default.
• W2036419595 cites W1978414000 @default.
• W2036419595 cites W1978859651 @default.
• W2036419595 cites W1979069643 @default.
• W2036419595 cites W1980037874 @default.
• W2036419595 cites W1981004116 @default.
• W2036419595 cites W1981721373 @default.
• W2036419595 cites W1982186982 @default.
• W2036419595 cites W1982272158 @default.
• W2036419595 cites W1982772354 @default.
• W2036419595 cites W1982861439 @default.
• W2036419595 cites W1984633053 @default.
• W2036419595 cites W1985584248 @default.
• W2036419595 cites W1985666931 @default.
• W2036419595 cites W1987863585 @default.
• W2036419595 cites W1990510145 @default.
• W2036419595 cites W1992199903 @default.
• W2036419595 cites W1993021425 @default.
• W2036419595 cites W1994469108 @default.
• W2036419595 cites W1995827857 @default.
• W2036419595 cites W1996303668 @default.
• W2036419595 cites W1998325637 @default.
• W2036419595 cites W1999579644 @default.
• W2036419595 cites W2001185486 @default.
• W2036419595 cites W2001296234 @default.
• W2036419595 cites W2004907588 @default.
• W2036419595 cites W2006896236 @default.
• W2036419595 cites W2007898486 @default.
• W2036419595 cites W2008018400 @default.
• W2036419595 cites W2008023528 @default.
• W2036419595 cites W2008290761 @default.
• W2036419595 cites W2009562693 @default.
• W2036419595 cites W2009867707 @default.
• W2036419595 cites W2011403734 @default.
• W2036419595 cites W2011745548 @default.
• W2036419595 cites W2013188292 @default.
• W2036419595 cites W2013818100 @default.
• W2036419595 cites W2014758132 @default.
• W2036419595 cites W2015343627 @default.
• W2036419595 cites W2016584979 @default.
• W2036419595 cites W2017422879 @default.
• W2036419595 cites W2021741218 @default.
• W2036419595 cites W2022177860 @default.
• W2036419595 cites W2022388148 @default.
• W2036419595 cites W2022474104 @default.
• W2036419595 cites W2023122926 @default.
• W2036419595 cites W2024230801 @default.
• W2036419595 cites W2025723617 @default.
• W2036419595 cites W2026803058 @default.
• W2036419595 cites W2026829115 @default.
• W2036419595 cites W2028970819 @default.
• W2036419595 cites W2029453461 @default.
• W2036419595 cites W2030338666 @default.
• W2036419595 cites W2032562223 @default.
• W2036419595 cites W2033283725 @default.

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