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- W2036420555 abstract "To determine whether riluzole is associated with blood pressure elevations in patients with amyotrophic lateral sclerosis (ALS).Though previously reported, hypertension is not considered a frequent adverse effect of riluzole.We reviewed data from 35 consecutive ALS patients on riluzole, and 88 randomly selected controls without and 20 patients with ALS who were not on riluzole.A significantly greater number of ALS patients on riluzole had blood pressure elevations (28 of 35 patients) compared to controls (26 of 88, p<0.001; 8 of 20, p = 0. 007). Median systolic and diastolic blood pressures were both significantly higher in riluzole-treated (140/86 mm Hg) than in control patients without ALS (120/70 mm Hg, p<0.001). Systolic, but not diastolic, blood pressures were significantly higher in riluzole-treated patients than in controls with ALS (126 mm Hg, p = 0.002).Riluzole treatment may be associated with mild blood pressure elevations. Future prospective trials of riluzole should closely assess hypertension." @default.
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- W2036420555 date "2000-01-01" @default.
- W2036420555 modified "2023-09-27" @default.
- W2036420555 title "Blood Pressure Elevations in Riluzole-Treated Patients with Amyotrophic Lateral Sclerosis" @default.
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- W2036420555 doi "https://doi.org/10.1159/000008180" @default.
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