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• W2036425674 abstract "In mammalian meiotic prophase, homologous chromosome recognition is aided by formation and repair of programmed DNA double-strand breaks (DSBs). Subsequently, stable associations form through homologous chromosome synapsis. In male mouse meiosis, the largely heterologous X and Y chromosomes synapse only in their short pseudoautosomal regions (PARs), and DSBs persist along the unsynapsed non-homologous arms of these sex chromosomes. Asynapsis of these arms and the persistent DSBs then trigger transcriptional silencing through meiotic sex chromosome inactivation (MSCI), resulting in formation of the XY body. This inactive state is partially maintained in post-meiotic haploid spermatids (postmeiotic sex chromatin repression, PSCR). For the human, establishment of MSCI and PSCR have also been reported, but X-linked gene silencing appears to be more variable compared to mouse. To gain more insight into the regulation and significance of MSCI and PSCR among different eutherian species, we have performed a global analysis of XY pairing dynamics, DSB repair, MSCI and PSCR in the domestic dog (Canis lupus familiaris), for which the complete genome sequence has recently become available, allowing a thorough comparative analyses. In addition to PAR synapsis between X and Y, we observed extensive self-synapsis of part of the dog X chromosome, and rapid loss of known markers of DSB repair from that part of the X. Sequencing of RNA from purified spermatocytes and spermatids revealed establishment of MSCI. However, the self-synapsing region of the X displayed higher X-linked gene expression compared to the unsynapsed area in spermatocytes, and was post-meiotically reactivated in spermatids. In contrast, genes in the PAR, which are expected to escape MSCI, were expressed at very low levels in both spermatocytes and spermatids. Our comparative analysis was then used to identify two X-linked genes that may escape MSCI in spermatocytes, and 21 that are specifically re-activated in spermatids of human, mouse and dog. Our data indicate that MSCI is incomplete in the dog. This may be partially explained by extensive, but transient, self-synapsis of the X chromosome, in association with rapid completion of meiotic DSB repair. In addition, our comparative analysis identifies novel candidate male fertility genes." @default.
• W2036425674 created "2016-06-24" @default.
• W2036425674 creator A5017573071 @default.
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• W2036425674 date "2015-04-12" @default.
• W2036425674 modified "2023-10-06" @default.
• W2036425674 title "Incomplete meiotic sex chromosome inactivation in the domestic dog" @default.
• W2036425674 cites W1480699894 @default.
• W2036425674 cites W149109563 @default.
• W2036425674 cites W1572586054 @default.
• W2036425674 cites W1606401780 @default.
• W2036425674 cites W1959403025 @default.
• W2036425674 cites W1963766206 @default.
• W2036425674 cites W1963998725 @default.
• W2036425674 cites W1965195727 @default.
• W2036425674 cites W1966170126 @default.
• W2036425674 cites W1967313027 @default.
• W2036425674 cites W1971887411 @default.
• W2036425674 cites W1972809713 @default.
• W2036425674 cites W1975334494 @default.
• W2036425674 cites W1981210505 @default.
• W2036425674 cites W1983668227 @default.
• W2036425674 cites W1986531164 @default.
• W2036425674 cites W1988698172 @default.
• W2036425674 cites W1992714434 @default.
• W2036425674 cites W1998958515 @default.
• W2036425674 cites W2001341582 @default.
• W2036425674 cites W2004497836 @default.
• W2036425674 cites W2006160555 @default.
• W2036425674 cites W2007074774 @default.
• W2036425674 cites W2009715519 @default.
• W2036425674 cites W2009726662 @default.
• W2036425674 cites W2009956340 @default.
• W2036425674 cites W2010133343 @default.
• W2036425674 cites W2011867412 @default.
• W2036425674 cites W2016492976 @default.
• W2036425674 cites W2020551877 @default.
• W2036425674 cites W2031655127 @default.
• W2036425674 cites W2038237542 @default.
• W2036425674 cites W2050692065 @default.
• W2036425674 cites W2053325896 @default.
• W2036425674 cites W2054266967 @default.
• W2036425674 cites W2059265921 @default.
• W2036425674 cites W2059315656 @default.
• W2036425674 cites W2061919774 @default.
• W2036425674 cites W2063292930 @default.
• W2036425674 cites W2074678950 @default.
• W2036425674 cites W2077296518 @default.
• W2036425674 cites W2078010067 @default.
• W2036425674 cites W2078276012 @default.
• W2036425674 cites W2078578601 @default.
• W2036425674 cites W2079004698 @default.
• W2036425674 cites W2081678663 @default.
• W2036425674 cites W2084969545 @default.
• W2036425674 cites W2088255591 @default.
• W2036425674 cites W2089001645 @default.
• W2036425674 cites W2089321487 @default.
• W2036425674 cites W2093363059 @default.
• W2036425674 cites W2095381776 @default.
• W2036425674 cites W2097727084 @default.
• W2036425674 cites W2097891387 @default.
• W2036425674 cites W2098456722 @default.
• W2036425674 cites W2098866515 @default.
• W2036425674 cites W2105550401 @default.
• W2036425674 cites W2106014350 @default.
• W2036425674 cites W2114104545 @default.
• W2036425674 cites W2114531852 @default.
• W2036425674 cites W2114611642 @default.
• W2036425674 cites W2118277313 @default.
• W2036425674 cites W2123049456 @default.
• W2036425674 cites W2123318581 @default.
• W2036425674 cites W2125508721 @default.
• W2036425674 cites W2126084304 @default.
• W2036425674 cites W2129214044 @default.
• W2036425674 cites W2129487614 @default.
• W2036425674 cites W2130884140 @default.
• W2036425674 cites W2132339381 @default.
• W2036425674 cites W2133894023 @default.
• W2036425674 cites W2135640276 @default.
• W2036425674 cites W2136275081 @default.
• W2036425674 cites W2137131184 @default.
• W2036425674 cites W2140159026 @default.
• W2036425674 cites W2141458291 @default.
• W2036425674 cites W2143817569 @default.
• W2036425674 cites W2144684946 @default.
• W2036425674 cites W2144686577 @default.
• W2036425674 cites W2147295960 @default.
• W2036425674 cites W2151548788 @default.
• W2036425674 cites W2152520334 @default.
• W2036425674 cites W2154473302 @default.

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