FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036463225> ?p ?o ?g. }

• W2036463225 endingPage "9" @default.
• W2036463225 startingPage "1" @default.
• W2036463225 abstract "In its blood stages the malaria parasite, Plasmodium, displays very high lipid metabolism. We present evidence for an abundant long-chain acyl-CoA synthetase (EC 6.2.1.3) activity in Plasmodium knowlesi-infected simian erythrocytes. The activity was found to be 20-fold higher in the schizont-infected (the last parasite stage) than in control erythrocytes. The cosubstrate requirements of the enzyme were similar to those previously reported for acyl-CoA synthetases from other sources. Among the separated reaction products of oleyl-CoA synthetase, only PPi and oleyl-CoA were inhibitory, with Ki over 350 microM. The fatty acid specificity of the parasite acyl-CoA synthetase activity was fairly marked and depended on the unsaturation state of the substrate. The tested fatty acids displayed similar Vmax, whereas their Km ranged from 11 (palmitate) to 59 microM (arachidonate). Finally, experiments involving heat inactivation and separation on hydroxyapatite excluded the presence of a specific arachidonyl-CoA synthetase identical to those present in other cells. On the other hand, fatty acid competition experiments evidenced the existence of at least two distinct enzymatic sites for fatty acid activation in P. knowlesi-infected simian erythrocytes: one is specific for saturated fatty acids and the other for polyunsaturated species, whereas oleate could be activated at both sites." @default.
• W2036463225 created "2016-06-24" @default.
• W2036463225 creator A5061413916 @default.
• W2036463225 creator A5061968830 @default.
• W2036463225 date "1988-01-01" @default.
• W2036463225 modified "2023-09-25" @default.
• W2036463225 title "Acyl-CoA synthetase activity in Plasmodium knowlesi-infected erythrocytes displays peculiar substrate specificities" @default.
• W2036463225 cites W1481587329 @default.
• W2036463225 cites W1482401645 @default.
• W2036463225 cites W1484056972 @default.
• W2036463225 cites W1499640544 @default.
• W2036463225 cites W1501304658 @default.
• W2036463225 cites W1517529383 @default.
• W2036463225 cites W1525945966 @default.
• W2036463225 cites W1570557409 @default.
• W2036463225 cites W1572595133 @default.
• W2036463225 cites W1574509858 @default.
• W2036463225 cites W1577075831 @default.
• W2036463225 cites W1633565009 @default.
• W2036463225 cites W1775749144 @default.
• W2036463225 cites W181452442 @default.
• W2036463225 cites W1981379940 @default.
• W2036463225 cites W1991055706 @default.
• W2036463225 cites W1997865316 @default.
• W2036463225 cites W2016210732 @default.
• W2036463225 cites W2017122138 @default.
• W2036463225 cites W2022418034 @default.
• W2036463225 cites W2030814140 @default.
• W2036463225 cites W2032637074 @default.
• W2036463225 cites W2037052841 @default.
• W2036463225 cites W2042745306 @default.
• W2036463225 cites W2055487041 @default.
• W2036463225 cites W2059284253 @default.
• W2036463225 cites W2062150611 @default.
• W2036463225 cites W2066300938 @default.
• W2036463225 cites W2084487887 @default.
• W2036463225 cites W2091062402 @default.
• W2036463225 cites W2093440481 @default.
• W2036463225 cites W2102083512 @default.
• W2036463225 cites W2168526937 @default.
• W2036463225 cites W2220565486 @default.
• W2036463225 cites W2303734138 @default.
• W2036463225 cites W2317954243 @default.
• W2036463225 cites W2396691124 @default.
• W2036463225 cites W4230919884 @default.
• W2036463225 cites W4255071083 @default.
• W2036463225 doi "https://doi.org/10.1016/0005-2760(88)90239-1" @default.
• W2036463225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3334857" @default.
• W2036463225 hasPublicationYear "1988" @default.
• W2036463225 type Work @default.
• W2036463225 sameAs 2036463225 @default.
• W2036463225 citedByCount "19" @default.
• W2036463225 countsByYear W20364632252012 @default.
• W2036463225 countsByYear W20364632252013 @default.
• W2036463225 countsByYear W20364632252014 @default.
• W2036463225 countsByYear W20364632252019 @default.
• W2036463225 countsByYear W20364632252023 @default.
• W2036463225 crossrefType "journal-article" @default.
• W2036463225 hasAuthorship W2036463225A5061413916 @default.
• W2036463225 hasAuthorship W2036463225A5061968830 @default.
• W2036463225 hasConcept C134651460 @default.
• W2036463225 hasConcept C181199279 @default.
• W2036463225 hasConcept C185592680 @default.
• W2036463225 hasConcept C18903297 @default.
• W2036463225 hasConcept C19038510 @default.
• W2036463225 hasConcept C201268389 @default.
• W2036463225 hasConcept C203014093 @default.
• W2036463225 hasConcept C2777289219 @default.
• W2036463225 hasConcept C2778048844 @default.
• W2036463225 hasConcept C2778371730 @default.
• W2036463225 hasConcept C2779123261 @default.
• W2036463225 hasConcept C2779997623 @default.
• W2036463225 hasConcept C2780559468 @default.
• W2036463225 hasConcept C43617362 @default.
• W2036463225 hasConcept C543025807 @default.
• W2036463225 hasConcept C55493867 @default.
• W2036463225 hasConcept C62231903 @default.
• W2036463225 hasConcept C86803240 @default.
• W2036463225 hasConceptScore W2036463225C134651460 @default.
• W2036463225 hasConceptScore W2036463225C181199279 @default.
• W2036463225 hasConceptScore W2036463225C185592680 @default.
• W2036463225 hasConceptScore W2036463225C18903297 @default.
• W2036463225 hasConceptScore W2036463225C19038510 @default.
• W2036463225 hasConceptScore W2036463225C201268389 @default.
• W2036463225 hasConceptScore W2036463225C203014093 @default.
• W2036463225 hasConceptScore W2036463225C2777289219 @default.
• W2036463225 hasConceptScore W2036463225C2778048844 @default.
• W2036463225 hasConceptScore W2036463225C2778371730 @default.
• W2036463225 hasConceptScore W2036463225C2779123261 @default.
• W2036463225 hasConceptScore W2036463225C2779997623 @default.
• W2036463225 hasConceptScore W2036463225C2780559468 @default.
• W2036463225 hasConceptScore W2036463225C43617362 @default.
• W2036463225 hasConceptScore W2036463225C543025807 @default.
• W2036463225 hasConceptScore W2036463225C55493867 @default.
• W2036463225 hasConceptScore W2036463225C62231903 @default.
• W2036463225 hasConceptScore W2036463225C86803240 @default.
• W2036463225 hasIssue "1" @default.
• W2036463225 hasLocation W20364632251 @default.

• next