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• W2036478410 abstract "Radium is of great value in the treatment of accessible recurrent carcinomata of the breast, as is illustrated by the following case: Woman, married, white, age 55, No. 8723, admitted to the Howard A. Kelly Hospital, for radium treatment December 8, 1921. General condition as to weight and color, good. The left side of chest presented a circular granulating area 9 x 9 cm., and a number of recurrent nodules protruding through areas partly covered with skin grafts. The condition was an extensive fixed recurrent carcinoma of the left chest wall. The opposite breast, axillary and neck regions, as well as the chest and abdomen, were clear of disease. Wassermann negative. Tissue taken presented a condition of adenocarcinoma. On April 17, 1919, a radical removal of the left breast and glands of the axilla, which were also involved, had been carried out at the Johns Hopkins Hospital. By means of skin grafts, healing had occurred. Recurrence had appeared, which necessitated removal of the cartilaginous portions of the third, fourth and fifth ribs on the left side. Immediate recurrence had followed, and a further removal of a portion of the ribs and sternum had been carried out September 14, 1921. Treatment was arranged for so that at a distance of 5 cm. through 1 m.m. brass and 2 m.m. lead a pure gamma radiation was secured over and well beyond the entire involved area. The first treatment was given December 9, 1921, for a total of sixteen gram hours. The area covered was approximately ninety square inches. A mild erythema of the skin and a marked recession of the growth were obtained. On January 7, 1922, a similar treatment was carried out covering but forty square inches, which now included the entire involved area. On February 18, 1922, this same area was treated, receiving a total of ten gram hours at 2½ cm. distance. This was followed by complete healing. However, on July 28, 1922, a small nodule appeared on the inner edge of the scar and was treated at a distance of 2 cm. for one gram hour. This resulted in a disappearance of the recurrence and there has been no further development of either local or general trouble. She was last examined July 10, 1925. Remarks Healing was secured in this case without sloughing or burning. The growth was an adenocarcinoma, which is more likely to heal than a hard scirrhous carcinoma. The intermittent radiation employed in this case is less trying on the patient and less likely to produce a burn than the single dose method. In extensive comparisons in parallel series it is our impression that radium gamma radiation is markedly superior to X-radiation of approximately equal quantity. When the growth is massively nodular the burying of bare emanation points must be added to the technic described above." @default.
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• W2036478410 date "1925-10-01" @default.
• W2036478410 modified "2023-09-26" @default.
• W2036478410 title "A Case Illustrating the Value of Radium in Recurrent Carcinoma of the Breast" @default.
• W2036478410 doi "https://doi.org/10.1148/5.4.343" @default.
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