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• W2036483152 abstract "Purpose/Objective(s)Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel experimental drug used as anti-fibrotic agent. This study was undertaken to investigate the effect of pirfenidone on prevention of radiation-induced lung toxicity.Materials/MethodsMale BALB/C mice were randomized into 4 groups: Control (group C); Radiation alone (group R); Pirfenidone alone (group P); Radiation + Pirfenidone (group R+P). Either sham irradiation (groups C and P) or single fraction of 12 Gy to whole thorax (groups R and R+P) were given to the animals. The animals were fed with control diet or same diet plus 0.5% Pirfenidone from 3 days prior to irradiation to 12 weeks after irradiation. The animals (6-8 mice per group) were sacrificed 1, 2, 3, 4, 5, 6 months after irradiation. Bronchoalveolar lavage fluid (BALF) from the right lungs was collected for detection of cell counting, and the left lungs were collected for hydroxyproline measurement or fixed for Masson trichrome staining. The plasm transforming growth factor β (TGF-β) was measured with ELISA method. T test and chi-square were used for statistical analysis.ResultsMacrophages in BALF were dramatically increased in the R and R+P groups at 4, 5, and 6 months after irradiation, but the number of macrophages were lower in group R than in group R+P (18.51×104/ml vs. 4.50 ×104/ml p = 0.005; 60.61×104/ml vs. 23.05×104/ml p = 0.046; 46.24×104/ml vs. 35.00×104/ml p = 0.305). Plasma TGF-β level in group R+P was lower comparing to that in group R at 3, 4, and 5 months after irradiation, but not statistically significant (3.48 pg/ml vs. 5.03 pg/ml p = 0.223; 3.82pg/ml vs. 5.31 pg/ml p = 0.666; 3.31pg/ml vs. 4.27pg/ml p = 0.310). Total lung hydroxyproline content, an index of fibrosis, was gradually increased with time in both group R and group R+P. But the level in R+P group were 21%, 24% lower comparing to group R at 4 and 5 months (86.1 μg/lung vs. 67.7 μg/lung p = 0.007; 104.1 μg/lung vs. 79.2 μg/lung p = 0.001). Based on Masson trichrome staining, we found that pirfenidone can ameliorate the severity of lung fibrosis at 4, 5, and 6 months after irradiation, the mean fibrosis score was higher in group R than in group R+P (47.50 vs. 20.30 p = 0.003; 47.91 vs. 29.15 p = 0.039; 42.50 vs. 19.46 p = 0.000).ConclusionsPirfenidone has a protective effect on radiation-induced lung toxicity in mice. Purpose/Objective(s)Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel experimental drug used as anti-fibrotic agent. This study was undertaken to investigate the effect of pirfenidone on prevention of radiation-induced lung toxicity. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel experimental drug used as anti-fibrotic agent. This study was undertaken to investigate the effect of pirfenidone on prevention of radiation-induced lung toxicity. Materials/MethodsMale BALB/C mice were randomized into 4 groups: Control (group C); Radiation alone (group R); Pirfenidone alone (group P); Radiation + Pirfenidone (group R+P). Either sham irradiation (groups C and P) or single fraction of 12 Gy to whole thorax (groups R and R+P) were given to the animals. The animals were fed with control diet or same diet plus 0.5% Pirfenidone from 3 days prior to irradiation to 12 weeks after irradiation. The animals (6-8 mice per group) were sacrificed 1, 2, 3, 4, 5, 6 months after irradiation. Bronchoalveolar lavage fluid (BALF) from the right lungs was collected for detection of cell counting, and the left lungs were collected for hydroxyproline measurement or fixed for Masson trichrome staining. The plasm transforming growth factor β (TGF-β) was measured with ELISA method. T test and chi-square were used for statistical analysis. Male BALB/C mice were randomized into 4 groups: Control (group C); Radiation alone (group R); Pirfenidone alone (group P); Radiation + Pirfenidone (group R+P). Either sham irradiation (groups C and P) or single fraction of 12 Gy to whole thorax (groups R and R+P) were given to the animals. The animals were fed with control diet or same diet plus 0.5% Pirfenidone from 3 days prior to irradiation to 12 weeks after irradiation. The animals (6-8 mice per group) were sacrificed 1, 2, 3, 4, 5, 6 months after irradiation. Bronchoalveolar lavage fluid (BALF) from the right lungs was collected for detection of cell counting, and the left lungs were collected for hydroxyproline measurement or fixed for Masson trichrome staining. The plasm transforming growth factor β (TGF-β) was measured with ELISA method. T test and chi-square were used for statistical analysis. ResultsMacrophages in BALF were dramatically increased in the R and R+P groups at 4, 5, and 6 months after irradiation, but the number of macrophages were lower in group R than in group R+P (18.51×104/ml vs. 4.50 ×104/ml p = 0.005; 60.61×104/ml vs. 23.05×104/ml p = 0.046; 46.24×104/ml vs. 35.00×104/ml p = 0.305). Plasma TGF-β level in group R+P was lower comparing to that in group R at 3, 4, and 5 months after irradiation, but not statistically significant (3.48 pg/ml vs. 5.03 pg/ml p = 0.223; 3.82pg/ml vs. 5.31 pg/ml p = 0.666; 3.31pg/ml vs. 4.27pg/ml p = 0.310). Total lung hydroxyproline content, an index of fibrosis, was gradually increased with time in both group R and group R+P. But the level in R+P group were 21%, 24% lower comparing to group R at 4 and 5 months (86.1 μg/lung vs. 67.7 μg/lung p = 0.007; 104.1 μg/lung vs. 79.2 μg/lung p = 0.001). Based on Masson trichrome staining, we found that pirfenidone can ameliorate the severity of lung fibrosis at 4, 5, and 6 months after irradiation, the mean fibrosis score was higher in group R than in group R+P (47.50 vs. 20.30 p = 0.003; 47.91 vs. 29.15 p = 0.039; 42.50 vs. 19.46 p = 0.000). Macrophages in BALF were dramatically increased in the R and R+P groups at 4, 5, and 6 months after irradiation, but the number of macrophages were lower in group R than in group R+P (18.51×104/ml vs. 4.50 ×104/ml p = 0.005; 60.61×104/ml vs. 23.05×104/ml p = 0.046; 46.24×104/ml vs. 35.00×104/ml p = 0.305). Plasma TGF-β level in group R+P was lower comparing to that in group R at 3, 4, and 5 months after irradiation, but not statistically significant (3.48 pg/ml vs. 5.03 pg/ml p = 0.223; 3.82pg/ml vs. 5.31 pg/ml p = 0.666; 3.31pg/ml vs. 4.27pg/ml p = 0.310). Total lung hydroxyproline content, an index of fibrosis, was gradually increased with time in both group R and group R+P. But the level in R+P group were 21%, 24% lower comparing to group R at 4 and 5 months (86.1 μg/lung vs. 67.7 μg/lung p = 0.007; 104.1 μg/lung vs. 79.2 μg/lung p = 0.001). Based on Masson trichrome staining, we found that pirfenidone can ameliorate the severity of lung fibrosis at 4, 5, and 6 months after irradiation, the mean fibrosis score was higher in group R than in group R+P (47.50 vs. 20.30 p = 0.003; 47.91 vs. 29.15 p = 0.039; 42.50 vs. 19.46 p = 0.000). ConclusionsPirfenidone has a protective effect on radiation-induced lung toxicity in mice. Pirfenidone has a protective effect on radiation-induced lung toxicity in mice." @default.
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• W2036483152 title "Effects of Pirfenidone on Prevention of Radiation-induced Lung Toxicity - Results of an Animal Experiment" @default.
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