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• W2036494529 abstract "ABSTRACT In Bacillus subtilis , the response regulator DegU and its cognate kinase, DegS, constitute a two-component system that regulates many cellular processes, including exoprotease production and genetic competence. Phosphorylated DegU (DegU-P) activates its own promoter and is degraded by the ClpCP protease. We observed induction of degU by glucose in sporulation medium. This was abolished in two mutants: the ccpA (catabolite control protein A) and clpC disruptants. Transcription of the promoter of the operon containing clpC (PclpC) decreased in the presence of glucose, and the disruption of ccpA resulted in derepression of PclpC. However, this was not directly mediated by CcpA, because we failed to detect binding of CcpA to PclpC. Glucose decreased the expression of clpC , leading to low cellular concentrations of the ClpCP protease. Thus, degU is induced through activation of autoregulation by a decrease in ClpCP-dependent proteolysis of DegU-P. An electrophoretic mobility shift assay showed that CcpA bound directly to the degU upstream region, indicating that CcpA activates degU through binding. The bound region was narrowed down to 27 bases, which contained a cre ( c atabolite- r esponsive e lement) sequence with a low match to the cre consensus sequence. In a footprint analysis, CcpA specifically protected a region containing the cre sequence from DNase I digestion. The induction of degU by glucose showed complex regulation of the degU gene." @default.
• W2036494529 created "2016-06-24" @default.
• W2036494529 creator A5016151821 @default.
• W2036494529 creator A5076331681 @default.
• W2036494529 creator A5089081003 @default.
• W2036494529 date "2013-01-15" @default.
• W2036494529 modified "2023-10-16" @default.
• W2036494529 title "The Bacillus subtilis Response Regulator Gene <i>degU</i> Is Positively Regulated by CcpA and by Catabolite-Repressed Synthesis of ClpC" @default.
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• W2036494529 doi "https://doi.org/10.1128/jb.01881-12" @default.
• W2036494529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3553847" @default.
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