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- W2036496114 abstract "Endothelin-3 (1 nmol/kg) given i.v. to anaesthetised rabbits significantly inhibited ADP-induced ex vivo platelet aggregation, while causing only a transient decrease in blood pressure and no change in heart rate. Pretreatment with piroxicam (14 mumol/kg) abolished the anti-aggregatory effect. Thus, endothelin-3, while not inhibiting rabbit platelets in vitro, can induce the release of a cyclo-oxygenase produce, probably prostacyclin, which inhibits ex vivo aggregation. Unlike endothelin-1, this was achieved with minimal effect on the haemodynamics." @default.
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- W2036496114 date "1989-07-01" @default.
- W2036496114 modified "2023-09-28" @default.
- W2036496114 title "Endothelin-3: selectivity as an anti-aggregatory peptide in vivo" @default.
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- W2036496114 doi "https://doi.org/10.1016/0014-2999(89)90079-4" @default.
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