FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036502020> ?p ?o ?g. }

• W2036502020 endingPage "231" @default.
• W2036502020 startingPage "217" @default.
• W2036502020 abstract "The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle progression until all kinetochores have attached to the mitotic spindle. In this paper, we show that the mitotic checkpoint kinase MPS1 contains an N-terminal localization module, organized in an N-terminal extension (NTE) and a tetratricopeptide repeat (TPR) domain, for which we have determined the crystal structure. Although the module was necessary for kinetochore localization of MPS1 and essential for the mitotic checkpoint, the predominant kinetochore binding activity resided within the NTE. MPS1 localization further required HEC1 and Aurora B activity. We show that MPS1 localization to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B–dependent phosphorylation of the HEC1 tail. Rather, the TPR domain was the critical mediator of Aurora B control over MPS1 localization, as its deletion rendered MPS1 localization insensitive to Aurora B inhibition. These data are consistent with a model in which Aurora B activity relieves a TPR-dependent inhibitory constraint on MPS1 localization." @default.
• W2036502020 created "2016-06-24" @default.
• W2036502020 creator A5000825842 @default.
• W2036502020 creator A5002467734 @default.
• W2036502020 creator A5014431830 @default.
• W2036502020 creator A5023718551 @default.
• W2036502020 creator A5040882011 @default.
• W2036502020 creator A5045168589 @default.
• W2036502020 creator A5062792929 @default.
• W2036502020 creator A5075798852 @default.
• W2036502020 creator A5086763911 @default.
• W2036502020 creator A5087012385 @default.
• W2036502020 date "2013-04-08" @default.
• W2036502020 modified "2023-10-16" @default.
• W2036502020 title "A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B" @default.
• W2036502020 cites W1797509927 @default.
• W2036502020 cites W1967115753 @default.
• W2036502020 cites W1969672293 @default.
• W2036502020 cites W1976418185 @default.
• W2036502020 cites W1982555128 @default.
• W2036502020 cites W1990438286 @default.
• W2036502020 cites W1995627045 @default.
• W2036502020 cites W1996847985 @default.
• W2036502020 cites W2015740282 @default.
• W2036502020 cites W2016500227 @default.
• W2036502020 cites W2023791134 @default.
• W2036502020 cites W2030517878 @default.
• W2036502020 cites W2035542044 @default.
• W2036502020 cites W2035852536 @default.
• W2036502020 cites W2037404897 @default.
• W2036502020 cites W2048225999 @default.
• W2036502020 cites W2048938594 @default.
• W2036502020 cites W2050415386 @default.
• W2036502020 cites W2055043387 @default.
• W2036502020 cites W2057334048 @default.
• W2036502020 cites W2059605618 @default.
• W2036502020 cites W2062117947 @default.
• W2036502020 cites W2063330798 @default.
• W2036502020 cites W2067284357 @default.
• W2036502020 cites W2068941785 @default.
• W2036502020 cites W2068972095 @default.
• W2036502020 cites W2069993260 @default.
• W2036502020 cites W2071156666 @default.
• W2036502020 cites W2072035559 @default.
• W2036502020 cites W2075909204 @default.
• W2036502020 cites W2079887269 @default.
• W2036502020 cites W2083363702 @default.
• W2036502020 cites W2089844705 @default.
• W2036502020 cites W2091556818 @default.
• W2036502020 cites W2096993351 @default.
• W2036502020 cites W2102094784 @default.
• W2036502020 cites W2102805328 @default.
• W2036502020 cites W2105989492 @default.
• W2036502020 cites W2110893691 @default.
• W2036502020 cites W2111069037 @default.
• W2036502020 cites W2111414057 @default.
• W2036502020 cites W2114460232 @default.
• W2036502020 cites W2117670891 @default.
• W2036502020 cites W2117752525 @default.
• W2036502020 cites W2124026197 @default.
• W2036502020 cites W2124092111 @default.
• W2036502020 cites W2124967403 @default.
• W2036502020 cites W2138122982 @default.
• W2036502020 cites W2143815085 @default.
• W2036502020 cites W2146470265 @default.
• W2036502020 cites W2148807789 @default.
• W2036502020 cites W2149127327 @default.
• W2036502020 cites W2151389002 @default.
• W2036502020 cites W2152603947 @default.
• W2036502020 cites W2155682217 @default.
• W2036502020 cites W2157471438 @default.
• W2036502020 cites W2159211495 @default.
• W2036502020 cites W2160378127 @default.
• W2036502020 cites W2160855984 @default.
• W2036502020 cites W2162895508 @default.
• W2036502020 cites W2163341755 @default.
• W2036502020 cites W2170141910 @default.
• W2036502020 cites W2171175279 @default.
• W2036502020 cites W4210675630 @default.
• W2036502020 doi "https://doi.org/10.1083/jcb.201210033" @default.
• W2036502020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3628519" @default.
• W2036502020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23569217" @default.
• W2036502020 hasPublicationYear "2013" @default.
• W2036502020 type Work @default.
• W2036502020 sameAs 2036502020 @default.
• W2036502020 citedByCount "117" @default.
• W2036502020 countsByYear W20365020202013 @default.
• W2036502020 countsByYear W20365020202014 @default.
• W2036502020 countsByYear W20365020202015 @default.
• W2036502020 countsByYear W20365020202016 @default.
• W2036502020 countsByYear W20365020202017 @default.
• W2036502020 countsByYear W20365020202018 @default.
• W2036502020 countsByYear W20365020202019 @default.
• W2036502020 countsByYear W20365020202020 @default.
• W2036502020 countsByYear W20365020202021 @default.
• W2036502020 countsByYear W20365020202022 @default.
• W2036502020 countsByYear W20365020202023 @default.
• W2036502020 crossrefType "journal-article" @default.

• next