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• W2036503561 abstract "Summary. Plasma concentrations of vitamin D metabolites in −17 non-pregnant women, 22 pregnant women at delivery, and in eight lactating women 3 and 16 days after delivery, were compared with those in a postpartum hypoparathyroid patient treated with 1α-hydroxyvitamin D (1α-OHD). The mean concentration of 1,25-dihydroxy vitamin D [1,25–(OH)2D] was 203 (SD 61) pmol/1 in the pregnant, and 86 (SD 27) pmol/1 in the non-pregnant women (P<0.0005). The levels 3. and 16 days after delivery were similar [57 (11) compared with 62 (19) pmol/1], and lower than the non-pregnant value (P<0.01). The 25-hydroxyvitamin D (25-OHD) concentration remained unchanged between the 3rd and 16th days after delivery, whereas the 24,25-dihydroxyvitamin D [24,25-(OH)2D] level increased from 2.7 (SD 1.8) to 3.7 (SD 2.3)nmol/l (P<0.025). The patient temporarily required an increased supplement of 1α-OHD during pregnancy, but a dose which was appropriate before pregnancy resulted in marked hypercalcaemia and a rise of 1,25-(OH)2D concentration within 16 days of delivery despite lactation. The results suggest that the metabolic need for the active vitamin D metabolite 1,25-(OH)2D is increased during pregnancy and rapidly reduced during early lactation in healthy and hypoparathyroid women." @default.
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• W2036503561 date "1983-10-01" @default.
• W2036503561 modified "2023-10-18" @default.
• W2036503561 title "Vitamin D metabolism in normal and hypoparathyroid pregnancy and lactation. Case report" @default.
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• W2036503561 doi "https://doi.org/10.1111/j.1471-0528.1983.tb06774.x" @default.
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