FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036518295> ?p ?o ?g. }

• W2036518295 endingPage "639" @default.
• W2036518295 startingPage "636" @default.
• W2036518295 abstract "Previous studies suggest that darbepoetin might stimulate erythropoiesis in preterm neonates more effectively if injected subcutaneously (s.c.) than if infused intravenously (i.v.). It has been postulated that this is because very high plasma concentrations after i.v. dosing result in urinary loss of the drug. However, this theory has not been tested systematically, and no direct comparisons have been made between s.c. and i.v. dosing of darbepoetin in preterm neonates.Preterm neonates were eligible for this pilot study if they were born at < or =32 weeks gestation with a weight of < or =1500 g, and had a hemoglobin < or =10.5 g/dl. The darbepoetin was given (4 microg/kg) i.v., over 4 h, if an i.v. was already in place and s.c. if no i.v. was in place. Urine was collected for drug quantification before dosing and for 48 h after. Blood was obtained for immature reticulocyte fraction (IRF), absolute reticulocyte count (ARC) and reticulocyte % before and 96 h after dosing.Ten preterm neonates were studied: five received i.v. and five received s.c. darbepoetin. No adverse effects of the administrations were detected. IRF, ARC and reticulocyte % increased in the i.v. and s.c. recipients, and no difference in magnitude of increase was apparent between the groups. Before the darbepoetin was administered, none of the patients had any erythropoietin (Epo) detected in their urine. After i.v. dosing, no darbepoetin was detected in any of the samples, on any of the subjects, over the subsequent 48 h. After s.c. dosing, three of the patients had minimal urinary Epo detected. The patient with the largest urinary loss of drug had only 0.13% of the administered dose detected in the urine. Thus, essentially no urinary loss of drug was observed following either i.v. or s.c. darbepoetin dosing.Darbepoetin loss into the urine was below detectable limits among seven patients, while three had minimally detectable urinary losses. i.v. and s.c. dosing resulted in approximately equivalent increases in reticulocyte response when measured 96 h after dosing. On this basis, we speculate that if a patient who is to receive darbepoetin has an i.v. in place, the drug can be given i.v., thus avoiding any discomfort associated with an s.c. injection." @default.
• W2036518295 created "2016-06-24" @default.
• W2036518295 creator A5005029676 @default.
• W2036518295 creator A5021626957 @default.
• W2036518295 creator A5022409904 @default.
• W2036518295 creator A5026854749 @default.
• W2036518295 creator A5078770575 @default.
• W2036518295 creator A5086999943 @default.
• W2036518295 date "2006-08-24" @default.
• W2036518295 modified "2023-10-15" @default.
• W2036518295 title "Urinary excretion of darbepoetin after intravenous vs subcutaneous administration to preterm neonates" @default.
• W2036518295 cites W1964818405 @default.
• W2036518295 cites W1994317582 @default.
• W2036518295 cites W2008517478 @default.
• W2036518295 cites W2013412830 @default.
• W2036518295 cites W2103941497 @default.
• W2036518295 cites W2137612567 @default.
• W2036518295 cites W2157752127 @default.
• W2036518295 cites W2169177790 @default.
• W2036518295 doi "https://doi.org/10.1038/sj.jp.7211596" @default.
• W2036518295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16929342" @default.
• W2036518295 hasPublicationYear "2006" @default.
• W2036518295 type Work @default.
• W2036518295 sameAs 2036518295 @default.
• W2036518295 citedByCount "19" @default.
• W2036518295 countsByYear W20365182952012 @default.
• W2036518295 countsByYear W20365182952013 @default.
• W2036518295 countsByYear W20365182952014 @default.
• W2036518295 countsByYear W20365182952015 @default.
• W2036518295 countsByYear W20365182952016 @default.
• W2036518295 countsByYear W20365182952018 @default.
• W2036518295 countsByYear W20365182952021 @default.
• W2036518295 crossrefType "journal-article" @default.
• W2036518295 hasAuthorship W2036518295A5005029676 @default.
• W2036518295 hasAuthorship W2036518295A5021626957 @default.
• W2036518295 hasAuthorship W2036518295A5022409904 @default.
• W2036518295 hasAuthorship W2036518295A5026854749 @default.
• W2036518295 hasAuthorship W2036518295A5078770575 @default.
• W2036518295 hasAuthorship W2036518295A5086999943 @default.
• W2036518295 hasBestOaLocation W20365182951 @default.
• W2036518295 hasConcept C10146269 @default.
• W2036518295 hasConcept C104317684 @default.
• W2036518295 hasConcept C105580179 @default.
• W2036518295 hasConcept C112705442 @default.
• W2036518295 hasConcept C126322002 @default.
• W2036518295 hasConcept C126894567 @default.
• W2036518295 hasConcept C185592680 @default.
• W2036518295 hasConcept C2777288759 @default.
• W2036518295 hasConcept C2778403015 @default.
• W2036518295 hasConcept C2778534260 @default.
• W2036518295 hasConcept C2780026642 @default.
• W2036518295 hasConcept C2781404941 @default.
• W2036518295 hasConcept C42407357 @default.
• W2036518295 hasConcept C55493867 @default.
• W2036518295 hasConcept C71924100 @default.
• W2036518295 hasConcept C77411442 @default.
• W2036518295 hasConceptScore W2036518295C10146269 @default.
• W2036518295 hasConceptScore W2036518295C104317684 @default.
• W2036518295 hasConceptScore W2036518295C105580179 @default.
• W2036518295 hasConceptScore W2036518295C112705442 @default.
• W2036518295 hasConceptScore W2036518295C126322002 @default.
• W2036518295 hasConceptScore W2036518295C126894567 @default.
• W2036518295 hasConceptScore W2036518295C185592680 @default.
• W2036518295 hasConceptScore W2036518295C2777288759 @default.
• W2036518295 hasConceptScore W2036518295C2778403015 @default.
• W2036518295 hasConceptScore W2036518295C2778534260 @default.
• W2036518295 hasConceptScore W2036518295C2780026642 @default.
• W2036518295 hasConceptScore W2036518295C2781404941 @default.
• W2036518295 hasConceptScore W2036518295C42407357 @default.
• W2036518295 hasConceptScore W2036518295C55493867 @default.
• W2036518295 hasConceptScore W2036518295C71924100 @default.
• W2036518295 hasConceptScore W2036518295C77411442 @default.
• W2036518295 hasIssue "10" @default.
• W2036518295 hasLocation W20365182951 @default.
• W2036518295 hasLocation W20365182952 @default.
• W2036518295 hasOpenAccess W2036518295 @default.
• W2036518295 hasPrimaryLocation W20365182951 @default.
• W2036518295 hasRelatedWork W2004714428 @default.
• W2036518295 hasRelatedWork W2114505956 @default.
• W2036518295 hasRelatedWork W2148674083 @default.
• W2036518295 hasRelatedWork W2154211481 @default.
• W2036518295 hasRelatedWork W2320239893 @default.
• W2036518295 hasRelatedWork W2377624422 @default.
• W2036518295 hasRelatedWork W2416062844 @default.
• W2036518295 hasRelatedWork W2417424508 @default.
• W2036518295 hasRelatedWork W4247164385 @default.
• W2036518295 hasRelatedWork W1985041333 @default.
• W2036518295 hasVolume "26" @default.
• W2036518295 isParatext "false" @default.
• W2036518295 isRetracted "false" @default.
• W2036518295 magId "2036518295" @default.
• W2036518295 workType "article" @default.