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• W2036526170 abstract "The past decade has borne witness to tremendous advances in our knowledge of the pathogenesis of psoriasis and the weight of evidence is now on the side of the T cell as being an integral mediator of this process. Advances in molecular technology have enabled direct in vivo measurement of cytokines and, although no animal model exists for the study of psoriasis, the use of cyclosporine has served as an excellent investigatory tool. The utilization of therapeutics to study psoriatic mechanisms is an unusual approach in that one must derive conclusions from disappearance of measurable factors such as cytokines and assume that these same factors are vital to the initiation and maintenance of a psoriatic plaque. Studying disease evolution using the Koebner phenomenon or relapse following treatment would supply a more accurate picture of initiating events. Based on the immune hypothesis, therapeutic modalities which are now entering the arena include T cell vaccination, particularly if psoriasis-specific T cell receptor Vβ-restricted clones can be isolated from psoriatic plaques. There is little doubt that by the end of this century, cutaneous biologists will have built substantially on the immunological foundation laid by the early work outlined here. Most likely the genetic contribution(s) to the manifestations of psoriasis will be more fully elucidated and that gene therapy will carry more than a futuristic promise. At least for the present we believe that such significant advances have been made that the majority of dermatologists if questioned nowadays as to whether psoriasis is an immunologically-mediated disease would answer in the affirmative." @default.
• W2036526170 created "2016-06-24" @default.
• W2036526170 creator A5005798011 @default.
• W2036526170 creator A5078821076 @default.
• W2036526170 date "1992-07-01" @default.
• W2036526170 modified "2023-09-27" @default.
• W2036526170 title "Immunological mechanisms involved in psoriasis" @default.
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