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• W2036530722 abstract "A highly sensitive electrochemical DNA sensor that requires no probe immobilization has been developed based on a target recycling mechanism utilizing a DNA polymerase with a strand displacement activity. The electrochemical detection is realized by taking advantage of the difference in diffusivity between a free ferrocene-labeled peptide nucleic acid (Fc-PNA) and a Fc-PNA hybridized with a complementary DNA, while the DNA polymerase-assisted target recycling leads to signal generation and amplification. The hybridization of the target DNA opens up a stem-loop template DNA with the Fc-PNA hybridized to its extruded 5′ end and allows a DNA primer to anneal and be extended by the DNA polymerase, which results in sequential displacement of the target DNA and the Fc-PNA from the template DNA. The displaced target DNA will hybridize with another template DNA, triggering another round of primer extension and strand displacement. The released Fc-PNA, due to its neutral backbone, has much higher diffusivity towards a negatively charged electrode, compared to that when it is hybridized with a negatively charged DNA. Therefore, a significantly enhanced signal of Fc can be observed. The outstanding sensitivity and simplicity make this approach a promising candidate for next-generation electrochemical DNA sensing technologies." @default.
• W2036530722 created "2016-06-24" @default.
• W2036530722 creator A5023725571 @default.
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• W2036530722 date "2012-05-01" @default.
• W2036530722 modified "2023-10-16" @default.
• W2036530722 title "Sensitive immobilization-free electrochemical DNA sensor based on isothermal circular strand displacement polymerization reaction" @default.
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• W2036530722 doi "https://doi.org/10.1016/j.bios.2012.02.054" @default.
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