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- W2036540489 abstract "SummaryThe inhibitory effects of azelastine hydrochloride on PAF-induced and fMLP-induced Ca2+ influx, actin polymerization and calcium ionophore A23187-induced and aggregated IgG-induced release of eosinophil cationic protein (ECP) of an eosinophilic leukaemia cell line, EoL-1, were examined. EoL-1 cells cultured with 0.2 mM dibutyryladenosine-cyclic monophosphate for 45, hours showed an increase in intracellular free Ca2+ concentration ([Ca2+]i) and actin polymerization when stimulated by PAF and fMLP Azelastine hydrochloride inhibited PAF-induced and fMLP-induced Ca2+influx ([Ca2+]i) in a dose-dependent manner with an IC50 of 1 × 10−-8M and 1 × 10−-7M, respectively. It also inhibited PAF-induced and fMLP-induced actin polymerization in a dose-dependent manner up to 40% and 30%, respectively. EoL-1 cells were differentiated to contain ECP in their eosinophilic granules when cultured for 9 days with supernatants of a human adult T cell leukaemia cell line, HIL-3 (HIL-3 sup). Calcium ionophore A23187 and aggregated IgG induced the secretion of ECP by EoL-1 cells. Azelastine hydrochloride inhibited the secretion of ECP in a dose-dependent manner. These inhibitory effects were seen even at therapeutic concentrations of 10−-8M to 10−-9M. These results indicate that the therapeutic effects of azelastine hydrochloride as an anti-allergic agent may include inhibition of the accumulation of eosinophils into the locus of allergic inflammation and of the release of cytotoxic granules from eosinophils." @default.
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- W2036540489 title "Inhibitory effects of azelastine hydrochloride on Ca<sup>2+</sup>influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1" @default.
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- W2036540489 doi "https://doi.org/10.1185/03007999309111546" @default.
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