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- W2036554878 endingPage "1314" @default.
- W2036554878 startingPage "1302" @default.
- W2036554878 abstract "Reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide, and hydroxyl radical, and reactive nitrogen species, such as nitric oxide and peroxynitrite, are biologically relevant O2 derivatives increasingly being recognized as important in vascular biology through their oxidation/reduction (redox) potential. All vascular cell types produce ROS primarily via membrane-associated NAD(P)H oxidase. ROS influence vascular function by modulating contraction/dilation, cell growth, apoptosis/anoikis, migration, inflammation, and fibrosis. An imbalance in redox state where prooxidants overwhelm antioxidant capacity results in oxidative stress. Oxidative excess and associated oxidative damage are mediators of altered vascular tone and structural remodeling in many cardiovascular diseases. ROS elicit these effects by influencing intracellular signaling events. In addition to modulating protein tyrosine kinases, protein phosphatases, mitogen-activated protein kinases, and transcription factors, ROS are important regulators of intracellular Ca2+ homeostasis and RhoA/Rho kinase signaling. ROS increase vascular [Ca2+]i by stimulating inositol trisphosphate-mediated Ca2+ mobilization, by increasing cytosolic Ca2+ accumulation through sarcoplasmic/endoplasmic reticulum Ca2+-ATPase inhibition, and by stimulating Ca2+ influx through Ca2+ channels. Increased ROS generation enhances Ca2+ signaling and up-regulates RhoA/Rho kinase, thereby altering vascular contractility and tone. The present review discusses the importance of ROS in angiotensin II signaling in vascular biology and focuses specifically on the role of oxidative stress in Ca2+ signaling in the vasculature.Antioxid. Redox Signal. 7, 1302–1314." @default.
- W2036554878 created "2016-06-24" @default.
- W2036554878 creator A5020577597 @default.
- W2036554878 date "2005-09-01" @default.
- W2036554878 modified "2023-10-12" @default.
- W2036554878 title "Reactive Oxygen Species as Mediators of Calcium Signaling by Angiotensin II: Implications in Vascular Physiology and Pathophysiology" @default.
- W2036554878 cites W1536437858 @default.
- W2036554878 cites W1572772426 @default.
- W2036554878 cites W1968529156 @default.
- W2036554878 cites W1969789360 @default.
- W2036554878 cites W1969901996 @default.
- W2036554878 cites W1972160596 @default.
- W2036554878 cites W1972467026 @default.
- W2036554878 cites W1977783092 @default.
- W2036554878 cites W1981905227 @default.
- W2036554878 cites W1981921279 @default.
- W2036554878 cites W1984054161 @default.
- W2036554878 cites W1990065094 @default.
- W2036554878 cites W1993950854 @default.
- W2036554878 cites W1998305917 @default.
- W2036554878 cites W1999349182 @default.
- W2036554878 cites W2000756775 @default.
- W2036554878 cites W2005294216 @default.
- W2036554878 cites W2005859137 @default.
- W2036554878 cites W2007101253 @default.
- W2036554878 cites W2007886276 @default.
- W2036554878 cites W2011239555 @default.
- W2036554878 cites W2012445850 @default.
- W2036554878 cites W2013216525 @default.
- W2036554878 cites W2013877830 @default.
- W2036554878 cites W2014180213 @default.
- W2036554878 cites W2016933143 @default.
- W2036554878 cites W2020319663 @default.
- W2036554878 cites W2029054651 @default.
- W2036554878 cites W2029298730 @default.
- W2036554878 cites W2029652412 @default.
- W2036554878 cites W2030279976 @default.
- W2036554878 cites W2031302525 @default.
- W2036554878 cites W2036811146 @default.
- W2036554878 cites W2038429888 @default.
- W2036554878 cites W2041148461 @default.
- W2036554878 cites W2041441757 @default.
- W2036554878 cites W2042769297 @default.
- W2036554878 cites W2045099525 @default.
- W2036554878 cites W2049045641 @default.
- W2036554878 cites W2050284449 @default.
- W2036554878 cites W2059187974 @default.
- W2036554878 cites W2059595504 @default.
- W2036554878 cites W2063198212 @default.
- W2036554878 cites W2066822664 @default.
- W2036554878 cites W2071919212 @default.
- W2036554878 cites W2076321627 @default.
- W2036554878 cites W2077298757 @default.
- W2036554878 cites W2077941478 @default.
- W2036554878 cites W2081192441 @default.
- W2036554878 cites W2084599949 @default.
- W2036554878 cites W2091723963 @default.
- W2036554878 cites W2094391023 @default.
- W2036554878 cites W2094848681 @default.
- W2036554878 cites W2098692806 @default.
- W2036554878 cites W2098854471 @default.
- W2036554878 cites W2099309899 @default.
- W2036554878 cites W2100566062 @default.
- W2036554878 cites W2101745219 @default.
- W2036554878 cites W2102202839 @default.
- W2036554878 cites W2102987835 @default.
- W2036554878 cites W2110712518 @default.
- W2036554878 cites W2110827050 @default.
- W2036554878 cites W2112244734 @default.
- W2036554878 cites W2114630275 @default.
- W2036554878 cites W2115239727 @default.
- W2036554878 cites W2120612885 @default.
- W2036554878 cites W2123799914 @default.
- W2036554878 cites W2126085531 @default.
- W2036554878 cites W2126524259 @default.
- W2036554878 cites W2129301938 @default.
- W2036554878 cites W2130395505 @default.
- W2036554878 cites W2132039169 @default.
- W2036554878 cites W2132878122 @default.
- W2036554878 cites W2133150758 @default.
- W2036554878 cites W2134665522 @default.
- W2036554878 cites W2135802281 @default.
- W2036554878 cites W2137630689 @default.
- W2036554878 cites W2139698292 @default.
- W2036554878 cites W2140660687 @default.
- W2036554878 cites W2145561716 @default.
- W2036554878 cites W2145898095 @default.
- W2036554878 cites W2146056013 @default.
- W2036554878 cites W2146960356 @default.
- W2036554878 cites W2147993424 @default.
- W2036554878 cites W2152399868 @default.
- W2036554878 cites W2159570527 @default.
- W2036554878 cites W2161045501 @default.
- W2036554878 cites W2161638887 @default.
- W2036554878 cites W2166669030 @default.
- W2036554878 cites W2168975002 @default.
- W2036554878 cites W2169878907 @default.
- W2036554878 cites W2169979796 @default.