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- W2036562294 endingPage "450" @default.
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- W2036562294 abstract "The initiation of X-chromosome inactivation in female mammals is controlled by a key locus, the X-inactivation centre (Xic). The Xist gene, which maps to the candidate region for Xic and is expressed exclusively from the inactive X chromosome, is thought to be an essential component of the Xic. To test whether sequences spanning several hundred kilobases and including Xist from the Xic region are capable of initiating inactivation, we have created a series of transgenic mice using a 460 kb yeast artificial chromosome (YAC). Analysis in these mice of the expression of Xist, of a LacZ reporter gene and of two genes in the region that are normally silent on the inactive X chromosome, suggests that essential sequences for Xist expression and X-inactivation may be absent in these transgenic animals." @default.
- W2036562294 created "2016-06-24" @default.
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- W2036562294 date "1996-04-01" @default.
- W2036562294 modified "2023-10-01" @default.
- W2036562294 title "Transgenic mice carrying an Xist-containing YAC" @default.
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- W2036562294 doi "https://doi.org/10.1093/hmg/5.4.441" @default.
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