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• W2036597764 abstract "A series of potent inhibitors of the sodium hydrogen exchanger-1 (NHE-1) is described. Structure–activity relationships identified the 3-methyl-4-fluoro analog 9t as a highly potent (IC50 = 0.0065 μM) and selective (NHE-2/NHE-1 = 1400) non-acylguanidine NHE-1 inhibitor. Pharmacokinetic studies showed that compound 9t has an oral bioavailability of 52% and a plasma half life of 1.5 h in rats. Because of its promising potency, selectivity, and a good pharmacokinetic profile, compound 9t was selected for further studies." @default.
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• W2036597764 date "2006-09-01" @default.
• W2036597764 modified "2023-10-16" @default.
• W2036597764 title "Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors" @default.
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• W2036597764 doi "https://doi.org/10.1016/j.bmcl.2006.06.077" @default.
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