FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036620430> ?p ?o ?g. }

• W2036620430 endingPage "e61024" @default.
• W2036620430 startingPage "e61024" @default.
• W2036620430 abstract "NK cells are a major component of the antitumour immune response that limits tumour progression. However, it has been reported that tumour-infiltrating NK (TINK) cells from patients with non-small-cell lung carcinoma (NSCLC) exhibit profound defects in degranulation and IFN-γ production. In support of this notion, we report a novel mechanism associated with tumour escape from NK cell-mediated antitumour immunity in lung carcinoma. In this study, we investigated the phenotypic profile of TINK cells based on the expression of the NK-cell maturation markers CD11b and CD27. Interestingly, we found a substantial CD11b(-)CD27(-) (DN) NK-cell population harboured within the tumour tissues. The presence of this CD11b(-)CD27(-) NK subset indicated that the TINK cells were of an immature and inactive phenotype. Remarkably, we determined that the presence of DN NK cells had an impact on the clinical outcomes of patients with NSCLC, as the frequency of tumour-infiltrating DN NK cells was positively correlated with the tumour stage and tumour size. We further used a murine Lewis lung cancer (LLC) model to confirm the correlation between the frequency of tumour-infiltrating DN NK cells and the progression of lung carcinoma. Together, our findings demonstrate that the tumour microenvironment may render TINK cells less tumouricidal and thereby contribute to cancer progression." @default.
• W2036620430 created "2016-06-24" @default.
• W2036620430 creator A5008578743 @default.
• W2036620430 creator A5012198733 @default.
• W2036620430 creator A5030306554 @default.
• W2036620430 creator A5041353057 @default.
• W2036620430 creator A5064617547 @default.
• W2036620430 creator A5082156574 @default.
• W2036620430 creator A5083130438 @default.
• W2036620430 date "2013-04-02" @default.
• W2036620430 modified "2023-10-06" @default.
• W2036620430 title "CD11b−CD27− NK Cells Are Associated with the Progression of Lung Carcinoma" @default.
• W2036620430 cites W1560092366 @default.
• W2036620430 cites W1565276921 @default.
• W2036620430 cites W1594123023 @default.
• W2036620430 cites W1661892624 @default.
• W2036620430 cites W1845250843 @default.
• W2036620430 cites W1943593754 @default.
• W2036620430 cites W1966315835 @default.
• W2036620430 cites W1969814796 @default.
• W2036620430 cites W1974308995 @default.
• W2036620430 cites W1989712520 @default.
• W2036620430 cites W1992780304 @default.
• W2036620430 cites W1992814804 @default.
• W2036620430 cites W1997849135 @default.
• W2036620430 cites W1998504569 @default.
• W2036620430 cites W2007169249 @default.
• W2036620430 cites W2009342562 @default.
• W2036620430 cites W2014522512 @default.
• W2036620430 cites W2025159260 @default.
• W2036620430 cites W2026089198 @default.
• W2036620430 cites W2027863196 @default.
• W2036620430 cites W2050752994 @default.
• W2036620430 cites W2060813234 @default.
• W2036620430 cites W2062961963 @default.
• W2036620430 cites W2063022052 @default.
• W2036620430 cites W2064920472 @default.
• W2036620430 cites W2064981157 @default.
• W2036620430 cites W2066011015 @default.
• W2036620430 cites W2067344082 @default.
• W2036620430 cites W2071294952 @default.
• W2036620430 cites W2071742694 @default.
• W2036620430 cites W2073300038 @default.
• W2036620430 cites W2075521813 @default.
• W2036620430 cites W2080588468 @default.
• W2036620430 cites W2081670280 @default.
• W2036620430 cites W2087590625 @default.
• W2036620430 cites W2089684997 @default.
• W2036620430 cites W2096449627 @default.
• W2036620430 cites W2109389423 @default.
• W2036620430 cites W2128066544 @default.
• W2036620430 cites W2130401210 @default.
• W2036620430 cites W2141436376 @default.
• W2036620430 cites W2143731593 @default.
• W2036620430 cites W2145890689 @default.
• W2036620430 cites W2146313292 @default.
• W2036620430 cites W2147448501 @default.
• W2036620430 cites W2153385228 @default.
• W2036620430 cites W2165144791 @default.
• W2036620430 cites W2166970460 @default.
• W2036620430 cites W2171709048 @default.
• W2036620430 cites W69353177 @default.
• W2036620430 doi "https://doi.org/10.1371/journal.pone.0061024" @default.
• W2036620430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3614924" @default.
• W2036620430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23565296" @default.
• W2036620430 hasPublicationYear "2013" @default.
• W2036620430 type Work @default.
• W2036620430 sameAs 2036620430 @default.
• W2036620430 citedByCount "32" @default.
• W2036620430 countsByYear W20366204302013 @default.
• W2036620430 countsByYear W20366204302014 @default.
• W2036620430 countsByYear W20366204302015 @default.
• W2036620430 countsByYear W20366204302016 @default.
• W2036620430 countsByYear W20366204302017 @default.
• W2036620430 countsByYear W20366204302018 @default.
• W2036620430 countsByYear W20366204302019 @default.
• W2036620430 countsByYear W20366204302020 @default.
• W2036620430 countsByYear W20366204302021 @default.
• W2036620430 countsByYear W20366204302022 @default.
• W2036620430 countsByYear W20366204302023 @default.
• W2036620430 crossrefType "journal-article" @default.
• W2036620430 hasAuthorship W2036620430A5008578743 @default.
• W2036620430 hasAuthorship W2036620430A5012198733 @default.
• W2036620430 hasAuthorship W2036620430A5030306554 @default.
• W2036620430 hasAuthorship W2036620430A5041353057 @default.
• W2036620430 hasAuthorship W2036620430A5064617547 @default.
• W2036620430 hasAuthorship W2036620430A5082156574 @default.
• W2036620430 hasAuthorship W2036620430A5083130438 @default.
• W2036620430 hasBestOaLocation W20366204301 @default.
• W2036620430 hasConcept C104317684 @default.
• W2036620430 hasConcept C121608353 @default.
• W2036620430 hasConcept C127716648 @default.
• W2036620430 hasConcept C142724271 @default.
• W2036620430 hasConcept C1491633281 @default.
• W2036620430 hasConcept C154317977 @default.
• W2036620430 hasConcept C170493617 @default.
• W2036620430 hasConcept C171779818 @default.
• W2036620430 hasConcept C202751555 @default.

• next