FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036625526> ?p ?o ?g. }

• W2036625526 endingPage "212" @default.
• W2036625526 startingPage "205" @default.
• W2036625526 abstract "Abstract Although most patients with chronic myeloid leukemia (CML) have the same initial molecular abnormality, the BCR-ABL fusion gene, the duration of chronic phase (CP) varies widely. To identify the possible molecular basis of this heterogeneity, we studied CD34+ cells collected at diagnosis from 68 patients with CML-CP. By using oligonucleotide microarray screening, we performed gene-expression profiling on 2 subsets of patients, one comprising patients with an “aggressive disease” who developed blastic transformation (BT) within 3 years of diagnosis (n = 10) and, at the other extreme, patients with an “indolent disease” whose BT occurred 7 or more years from diagnosis (n = 9). This screening revealed 20 genes differentially expressed in patients with aggressive and indolent disease, which were validated by quantitative reverse transcriptase/polymerase chain reaction (Q-RT/PCR). A multivariate Cox regression model identified the combination of low CD7 expression with high expression of proteinase 3 or elastase as associated with longer survival in the complete cohort of 68 patients. This differential pattern of gene expression probably reflects the intrinsic heterogeneity of the disease; if so, assessing expression levels of selected genes at diagnosis may be valuable in predicting duration of survival in patients treated with imatinib and the newer tyrosine kinase inhibitors." @default.
• W2036625526 created "2016-06-24" @default.
• W2036625526 creator A5020401806 @default.
• W2036625526 creator A5039305143 @default.
• W2036625526 creator A5042107262 @default.
• W2036625526 creator A5074115908 @default.
• W2036625526 creator A5087980705 @default.
• W2036625526 date "2006-01-01" @default.
• W2036625526 modified "2023-09-29" @default.
• W2036625526 title "Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML" @default.
• W2036625526 cites W120676909 @default.
• W2036625526 cites W1482758361 @default.
• W2036625526 cites W1589551152 @default.
• W2036625526 cites W1799579309 @default.
• W2036625526 cites W183737772 @default.
• W2036625526 cites W1976393396 @default.
• W2036625526 cites W1977728980 @default.
• W2036625526 cites W1987239635 @default.
• W2036625526 cites W2008267412 @default.
• W2036625526 cites W2016656445 @default.
• W2036625526 cites W2018279800 @default.
• W2036625526 cites W2018573817 @default.
• W2036625526 cites W2028959752 @default.
• W2036625526 cites W2032328941 @default.
• W2036625526 cites W2038437697 @default.
• W2036625526 cites W2041200806 @default.
• W2036625526 cites W2068517117 @default.
• W2036625526 cites W2068977368 @default.
• W2036625526 cites W2070299475 @default.
• W2036625526 cites W2079517811 @default.
• W2036625526 cites W2080552851 @default.
• W2036625526 cites W2083507808 @default.
• W2036625526 cites W2091947792 @default.
• W2036625526 cites W2092606584 @default.
• W2036625526 cites W2109972881 @default.
• W2036625526 cites W2112174940 @default.
• W2036625526 cites W2114959774 @default.
• W2036625526 cites W2117806883 @default.
• W2036625526 cites W2124196948 @default.
• W2036625526 cites W2125225535 @default.
• W2036625526 cites W2138218344 @default.
• W2036625526 cites W2141324982 @default.
• W2036625526 cites W2148763134 @default.
• W2036625526 cites W2154856176 @default.
• W2036625526 cites W2164872817 @default.
• W2036625526 cites W2170989872 @default.
• W2036625526 cites W2329648702 @default.
• W2036625526 cites W319578897 @default.
• W2036625526 cites W60903004 @default.
• W2036625526 cites W998391454 @default.
• W2036625526 doi "https://doi.org/10.1182/blood-2005-05-2155" @default.
• W2036625526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16144796" @default.
• W2036625526 hasPublicationYear "2006" @default.
• W2036625526 type Work @default.
• W2036625526 sameAs 2036625526 @default.
• W2036625526 citedByCount "146" @default.
• W2036625526 countsByYear W20366255262012 @default.
• W2036625526 countsByYear W20366255262013 @default.
• W2036625526 countsByYear W20366255262014 @default.
• W2036625526 countsByYear W20366255262015 @default.
• W2036625526 countsByYear W20366255262016 @default.
• W2036625526 countsByYear W20366255262017 @default.
• W2036625526 countsByYear W20366255262018 @default.
• W2036625526 countsByYear W20366255262019 @default.
• W2036625526 countsByYear W20366255262020 @default.
• W2036625526 countsByYear W20366255262021 @default.
• W2036625526 countsByYear W20366255262022 @default.
• W2036625526 countsByYear W20366255262023 @default.
• W2036625526 crossrefType "journal-article" @default.
• W2036625526 hasAuthorship W2036625526A5020401806 @default.
• W2036625526 hasAuthorship W2036625526A5039305143 @default.
• W2036625526 hasAuthorship W2036625526A5042107262 @default.
• W2036625526 hasAuthorship W2036625526A5074115908 @default.
• W2036625526 hasAuthorship W2036625526A5087980705 @default.
• W2036625526 hasBestOaLocation W20366255261 @default.
• W2036625526 hasConcept C10205521 @default.
• W2036625526 hasConcept C104317684 @default.
• W2036625526 hasConcept C111829193 @default.
• W2036625526 hasConcept C126322002 @default.
• W2036625526 hasConcept C143998085 @default.
• W2036625526 hasConcept C150194340 @default.
• W2036625526 hasConcept C170493617 @default.
• W2036625526 hasConcept C18431079 @default.
• W2036625526 hasConcept C203014093 @default.
• W2036625526 hasConcept C2777583451 @default.
• W2036625526 hasConcept C2778729363 @default.
• W2036625526 hasConcept C28328180 @default.
• W2036625526 hasConcept C3019892230 @default.
• W2036625526 hasConcept C42362537 @default.
• W2036625526 hasConcept C502942594 @default.
• W2036625526 hasConcept C50382708 @default.
• W2036625526 hasConcept C54355233 @default.
• W2036625526 hasConcept C71924100 @default.
• W2036625526 hasConcept C86803240 @default.
• W2036625526 hasConceptScore W2036625526C10205521 @default.
• W2036625526 hasConceptScore W2036625526C104317684 @default.
• W2036625526 hasConceptScore W2036625526C111829193 @default.
• W2036625526 hasConceptScore W2036625526C126322002 @default.

• next