Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036639619> ?p ?o ?g. }
- W2036639619 endingPage "458" @default.
- W2036639619 startingPage "450" @default.
- W2036639619 abstract "Using recent evidence from mouse models, this Review discusses whether p53-dependent senescence induced by dysfunctional telomeres is as potent as apoptosis in suppressing tumorigenesisin vivo. Long-lived organisms such as humans have evolved several intrinsic tumour suppressor mechanisms to combat the slew of oncogenic somatic mutations that constantly arise in proliferating stem-cell compartments. One of these anticancer barriers is the telomere, a specialized nucleoprotein complex that caps the ends of eukaryotic chromosome. Impaired telomere function activates the canonical DNA damage response pathway that engages p53 to initiate apoptosis or replicative senescence. Here, we discuss how p53-dependent senescence induced by dysfunctional telomeres may be as potent as apoptosis in suppressing tumorigenesis in vivo." @default.
- W2036639619 created "2016-06-24" @default.
- W2036639619 creator A5011341538 @default.
- W2036639619 creator A5081904414 @default.
- W2036639619 creator A5089335852 @default.
- W2036639619 date "2008-06-01" @default.
- W2036639619 modified "2023-10-16" @default.
- W2036639619 title "Telomere dysfunction and tumour suppression: the senescence connection" @default.
- W2036639619 cites W1483245334 @default.
- W2036639619 cites W1485522487 @default.
- W2036639619 cites W1543500873 @default.
- W2036639619 cites W1573467049 @default.
- W2036639619 cites W1612842202 @default.
- W2036639619 cites W1676646253 @default.
- W2036639619 cites W1829553711 @default.
- W2036639619 cites W1964543951 @default.
- W2036639619 cites W1966826646 @default.
- W2036639619 cites W1970378023 @default.
- W2036639619 cites W1970891016 @default.
- W2036639619 cites W1972655555 @default.
- W2036639619 cites W1973886069 @default.
- W2036639619 cites W1976273464 @default.
- W2036639619 cites W1980878904 @default.
- W2036639619 cites W1982199027 @default.
- W2036639619 cites W1982767015 @default.
- W2036639619 cites W1983673827 @default.
- W2036639619 cites W1984187829 @default.
- W2036639619 cites W1985910710 @default.
- W2036639619 cites W1985964699 @default.
- W2036639619 cites W1992430278 @default.
- W2036639619 cites W1993469796 @default.
- W2036639619 cites W1995365852 @default.
- W2036639619 cites W1995491393 @default.
- W2036639619 cites W1998663807 @default.
- W2036639619 cites W2000971601 @default.
- W2036639619 cites W2001733842 @default.
- W2036639619 cites W2003446723 @default.
- W2036639619 cites W2004314923 @default.
- W2036639619 cites W2011882274 @default.
- W2036639619 cites W2013073993 @default.
- W2036639619 cites W2015414930 @default.
- W2036639619 cites W2018369441 @default.
- W2036639619 cites W2021046086 @default.
- W2036639619 cites W2022507419 @default.
- W2036639619 cites W2024209230 @default.
- W2036639619 cites W2024619097 @default.
- W2036639619 cites W2026180657 @default.
- W2036639619 cites W2027779909 @default.
- W2036639619 cites W2027931017 @default.
- W2036639619 cites W2028320710 @default.
- W2036639619 cites W2030976397 @default.
- W2036639619 cites W2032407757 @default.
- W2036639619 cites W2034901235 @default.
- W2036639619 cites W2034962229 @default.
- W2036639619 cites W2035389897 @default.
- W2036639619 cites W2035552696 @default.
- W2036639619 cites W2043204829 @default.
- W2036639619 cites W2043740004 @default.
- W2036639619 cites W2049085719 @default.
- W2036639619 cites W2049151391 @default.
- W2036639619 cites W2051990601 @default.
- W2036639619 cites W2053271633 @default.
- W2036639619 cites W2053300345 @default.
- W2036639619 cites W2055185717 @default.
- W2036639619 cites W2055247766 @default.
- W2036639619 cites W2058375396 @default.
- W2036639619 cites W2059971436 @default.
- W2036639619 cites W2063062036 @default.
- W2036639619 cites W2063271191 @default.
- W2036639619 cites W2064208421 @default.
- W2036639619 cites W2065891752 @default.
- W2036639619 cites W2066058593 @default.
- W2036639619 cites W2067117191 @default.
- W2036639619 cites W2078805336 @default.
- W2036639619 cites W2080769506 @default.
- W2036639619 cites W2081237863 @default.
- W2036639619 cites W2081944825 @default.
- W2036639619 cites W2082559623 @default.
- W2036639619 cites W2086095857 @default.
- W2036639619 cites W2088512897 @default.
- W2036639619 cites W2094950317 @default.
- W2036639619 cites W2096107753 @default.
- W2036639619 cites W2098951927 @default.
- W2036639619 cites W2100550233 @default.
- W2036639619 cites W2102801302 @default.
- W2036639619 cites W2103899181 @default.
- W2036639619 cites W2104908670 @default.
- W2036639619 cites W2108482850 @default.
- W2036639619 cites W2122672345 @default.
- W2036639619 cites W2125250665 @default.
- W2036639619 cites W2125343208 @default.
- W2036639619 cites W2126407488 @default.
- W2036639619 cites W2126815966 @default.
- W2036639619 cites W2132606465 @default.
- W2036639619 cites W2134390575 @default.
- W2036639619 cites W2143285081 @default.
- W2036639619 cites W2145344158 @default.
- W2036639619 cites W2145357417 @default.