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• W2036640855 abstract "Two series of indenoisoquinoline topoisomerase I inhibitors have been prepared to investigate optimal substituents on the indenone ring at the 9-position. The more exhaustive series was prepared using a nitrated isoquinoline ring that has been previously demonstrated to enhance biological activity. After preliminary biological evaluation, a more focused series of inhibitors was prepared utilizing a 2,3-dimethoxy-substituted isoquinoline ring. The results of the two series indicate the existence of superior functional groups such as methoxy, fluorine, and cyano for the indenoisoquinoline 9-position. Interestingly, these functional groups coincide with established structure-activity relationships for the 11-position of camptothecin." @default.
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• W2036640855 date "2007-08-04" @default.
• W2036640855 modified "2023-10-17" @default.
• W2036640855 title "Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors" @default.
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• W2036640855 doi "https://doi.org/10.1021/jm070307+" @default.
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