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• W2036645967 abstract "We investigated the effect of ginsenoside Rg2 on neurotoxic activities induced by glutamate in PC12 cells. The cells were incubated with glutamate (1 mmol/L), glutamate and ginsenoside Rg2 (0.05, 0.1, 0.2 mmol/L) or nimodipine (5 μmol/L) for 24 h. The cellular viability was assessed by MTT assay. The lipid peroxidation products malondialdehyde (MDA) and nitrogen oxide (NO) were measured by a spectrophotometric method. Fura-2/AM, as a cell permeable fluorescent probe for Ca2+, was used to detect intracellular Ca2+ concentration ([Ca2+]i) using a monespectrofluorometer. Immunocytochemical techniques were employed to check the protein expression levels of calpain II, caspase-3 and β-amyloid (Aβ)1–40 in PC12 cells. The results showed that glutamate decreased the cell viability, increased [Ca2+]i, lipid peroxidation (the excessive production of MDA, NO) and the protein expression levels of calpain II, caspase-3 and Aβ1–40 in PC12 cells. Ginsenoside Rg2 significantly attenuated glutamate-induced neurotoxic effects upon these parameters at all doses tested. Our study suggests that ginsenoside Rg2 has a neuroprotective effect against glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis. In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Aβ1–40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease." @default.
• W2036645967 created "2016-06-24" @default.
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• W2036645967 date "2007-05-01" @default.
• W2036645967 modified "2023-10-01" @default.
• W2036645967 title "Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells" @default.
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• W2036645967 doi "https://doi.org/10.1016/j.jep.2006.12.015" @default.
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