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- W2036653357 abstract "The effect of pH on the active sodium transport of the isolated frog skin has been investigated. The sodium transport has previously been considered to be particularly sensitive to lowering of pH in the solution bathing the corium side of skin. However, when pH was lowered by unilateral titration with carbon dioxide, the active sodium transport was more sensitive to changes of pH on the epidermal side than on the corium side of the skin. Raising bicarbonate concentration from 2.4 to 57.5 or 115 mM increased the tolerance to carbon dioxide. This effect of bicarbonate was exerted from the corium side of the skin. The differing respones seen in the presence of 2.4, 57.5, and 115 mM bicarbonate showed no direct correlation to pH of the media. When phosphate concentration was below 1 mM, lowering of pH to values between 6.5 and 5.8 with HCI or H3 PO4 in the medium on the corium side had only slight effect on the sodium transport. At phosphate concentrations of 5—6 mM the transport was found to be inhibited rapidly. The results suggest that the active sodium transport of the isolated frog skin is affected by condition lowering the intracellular pH of the transporting cells." @default.
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- W2036653357 date "1967-08-01" @default.
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- W2036653357 title "The Effects of CO<sub>2</sub>and Hydrogen Ions on Active Na Transport in the Isolated Frog Skin" @default.
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- W2036653357 doi "https://doi.org/10.1111/j.1748-1716.1967.tb03710.x" @default.
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