Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036667067> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2036667067 abstract "Abstract The metabolism of [14C]pentobarbitone and [14C]phenobarbitone has been reinvestigated using an in-vitro hepatic microsomal system (Syrian hamsters, Aroclor 1254 induction). The incubation system was routinely supplemented with EDTA (1 mM) and a substrate concentration study revealed the metabolism of [14C]pentobarbitone to be concentration-dependent, with the greatest overall metabolism (>50%) occurring at 0.054 μmol per 3.5 mL. With [14C]phenobarbitone as substrate, overall metabolism was extremely low (3%) and independent of substrate concentration. Addition of further cofactors to the incubation mixture at 20 min intervals over an extended period resulted in almost complete metabolism of [14C]pentobarbitone (100 min), 3′-hydroxypentobarbitone and 3′-oxopentobarbitone being identified as metabolites together with many minor, unidentified products. With [14C]phenobarbitone as the substrate, cofactor addition up to 120 min resulted in 8% overall metabolism; p-hydroxyphenobarbitone was identified as a product of metabolism; other minor products were unidentified. The metabolism studies failed to produce a metabolite having the properties of the N-hydroxylated product of either [14C]pentobarbitone or [14C]phenobarbitone within the detection limits available (0.02% of 0.5 μmol per incubate)." @default.
- W2036667067 created "2016-06-24" @default.
- W2036667067 creator A5056778451 @default.
- W2036667067 creator A5088730760 @default.
- W2036667067 date "1987-02-01" @default.
- W2036667067 modified "2023-10-18" @default.
- W2036667067 title "The in-vitro metabolism of [14C]pentobarbitone and [14C]phenobarbitone by hamster liver microsomes" @default.
- W2036667067 cites W122738636 @default.
- W2036667067 cites W189238932 @default.
- W2036667067 cites W1951469402 @default.
- W2036667067 cites W1966717702 @default.
- W2036667067 cites W1968927346 @default.
- W2036667067 cites W1975565039 @default.
- W2036667067 cites W1976917904 @default.
- W2036667067 cites W2002702307 @default.
- W2036667067 cites W2004457064 @default.
- W2036667067 cites W2012962769 @default.
- W2036667067 cites W2013093816 @default.
- W2036667067 cites W2020483571 @default.
- W2036667067 cites W2034918477 @default.
- W2036667067 cites W2055598466 @default.
- W2036667067 cites W2066264664 @default.
- W2036667067 cites W2092340615 @default.
- W2036667067 cites W2156181827 @default.
- W2036667067 cites W2157050012 @default.
- W2036667067 cites W2436975333 @default.
- W2036667067 cites W1999262653 @default.
- W2036667067 doi "https://doi.org/10.1111/j.2042-7158.1987.tb06950.x" @default.
- W2036667067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2882009" @default.
- W2036667067 hasPublicationYear "1987" @default.
- W2036667067 type Work @default.
- W2036667067 sameAs 2036667067 @default.
- W2036667067 citedByCount "4" @default.
- W2036667067 crossrefType "journal-article" @default.
- W2036667067 hasAuthorship W2036667067A5056778451 @default.
- W2036667067 hasAuthorship W2036667067A5088730760 @default.
- W2036667067 hasConcept C134018914 @default.
- W2036667067 hasConcept C185592680 @default.
- W2036667067 hasConcept C18903297 @default.
- W2036667067 hasConcept C202751555 @default.
- W2036667067 hasConcept C25642318 @default.
- W2036667067 hasConcept C2777289219 @default.
- W2036667067 hasConcept C2777477808 @default.
- W2036667067 hasConcept C2778575167 @default.
- W2036667067 hasConcept C2778793413 @default.
- W2036667067 hasConcept C43617362 @default.
- W2036667067 hasConcept C55493867 @default.
- W2036667067 hasConcept C62231903 @default.
- W2036667067 hasConcept C86803240 @default.
- W2036667067 hasConcept C87644729 @default.
- W2036667067 hasConcept C89311334 @default.
- W2036667067 hasConcept C98274493 @default.
- W2036667067 hasConceptScore W2036667067C134018914 @default.
- W2036667067 hasConceptScore W2036667067C185592680 @default.
- W2036667067 hasConceptScore W2036667067C18903297 @default.
- W2036667067 hasConceptScore W2036667067C202751555 @default.
- W2036667067 hasConceptScore W2036667067C25642318 @default.
- W2036667067 hasConceptScore W2036667067C2777289219 @default.
- W2036667067 hasConceptScore W2036667067C2777477808 @default.
- W2036667067 hasConceptScore W2036667067C2778575167 @default.
- W2036667067 hasConceptScore W2036667067C2778793413 @default.
- W2036667067 hasConceptScore W2036667067C43617362 @default.
- W2036667067 hasConceptScore W2036667067C55493867 @default.
- W2036667067 hasConceptScore W2036667067C62231903 @default.
- W2036667067 hasConceptScore W2036667067C86803240 @default.
- W2036667067 hasConceptScore W2036667067C87644729 @default.
- W2036667067 hasConceptScore W2036667067C89311334 @default.
- W2036667067 hasConceptScore W2036667067C98274493 @default.
- W2036667067 hasLocation W20366670671 @default.
- W2036667067 hasLocation W20366670672 @default.
- W2036667067 hasOpenAccess W2036667067 @default.
- W2036667067 hasPrimaryLocation W20366670671 @default.
- W2036667067 hasRelatedWork W1974165727 @default.
- W2036667067 hasRelatedWork W1978748450 @default.
- W2036667067 hasRelatedWork W1988604752 @default.
- W2036667067 hasRelatedWork W2036667067 @default.
- W2036667067 hasRelatedWork W2037012505 @default.
- W2036667067 hasRelatedWork W2073719851 @default.
- W2036667067 hasRelatedWork W2084454449 @default.
- W2036667067 hasRelatedWork W2090709712 @default.
- W2036667067 hasRelatedWork W2280489731 @default.
- W2036667067 hasRelatedWork W2414004620 @default.
- W2036667067 isParatext "false" @default.
- W2036667067 isRetracted "false" @default.
- W2036667067 magId "2036667067" @default.
- W2036667067 workType "article" @default.