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- W2036673003 abstract "d-Sotalol was developed as an antiarrhythmic agent with a relative lack of antagonist activity at β-adrenergic receptors. Exercise heart rate reduction has been observed after administration to humans. The purpose of this study was to determine directly whether this effect of d-sotalol was attributable to β -blockade. Plasma samples from normal volunteers who randomly received either atenolol, d-sotalol, or placebo were used in an in vitro radioreceptor assay to determine occupancy of β-adrenergic receptors by antagonist present in the plasma. Occupancy was compared with the observed pharmacologie effects. A reduction in exercise heart rate of 7.7% ± 3.8% for d-sotalol and 15.9% ± 3.0% for atenolol occurred with β1-adrenergic receptor occupancy of 0% and 33.9% ± 21.4%, respectively. Absence of antagonist effect in the radioreceptor assay eliminates the potential role of β1-blockade in d-sotalol— induced heart rate reduction. This effect is most likely a result of prolongation of the sinus node action potential duration. Clinical Pharmacology and Therapeutics (1993) 53, 436–442; doi:10.1038/clpt.1993.48" @default.
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- W2036673003 date "1993-04-01" @default.
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- W2036673003 title "d-Sotalol reduces heart rate in vivo through a β-adrenergic receptor–independent mechanism" @default.
- W2036673003 doi "https://doi.org/10.1038/clpt.1993.48" @default.
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