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• W2036676885 abstract "The action of methotrexate, actinomycin D, bleomycin, vincristine and hydroxyurea on the production of human chorionic gonadotrophin (hCG) by a choriocarcinoma cell line (BeWo) has been studied. hCG production per unit of cell protein was increased, and this was a continuing process only halted by cell death. The proportion of hCG-producing cells in the population increased from approximately 5% to a maximum of approximately 40% during incubation with vincristine. A possible explanation for these and related observations is that cytotoxic agents promote the differentiation of cytotrophoblast to syncytium. A similar mechanism could contribute to the unusual sensitivity of choriocarcinoma to cytotoxic agents." @default.
• W2036676885 created "2016-06-24" @default.
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• W2036676885 date "1982-07-01" @default.
• W2036676885 modified "2023-10-07" @default.
• W2036676885 title "Enhancement of human chorionic gonadotrophin production by antimetabolites" @default.
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• W2036676885 doi "https://doi.org/10.1038/bjc.1982.160" @default.
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