Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036691084> ?p ?o ?g. }
- W2036691084 endingPage "6" @default.
- W2036691084 startingPage "1" @default.
- W2036691084 abstract "Abstract The pathogenesis of septic myocardial depression is complicated. Mitochondrial dysfunction has been suggested to be one of the main reasons for the reduced cardiac function. As melatonin is an antioxidant with the potential to scavenge radicals in mitochondria, we therefore employed a sepsis model, that is, cecal ligation and double puncture ( CLP ) in rats, to study the melatonin effects on: (i), myocardial mitochondrial function; (ii), heart systolic function; and (iii), prognosis of septic rats. We demonstrate that melatonin treatment (30 mg/kg, 3, 6, 12, 18, 24 hr after CLP ) (i) improved myocardial cytochrome c oxidase (Cc OX ) activity and blood lactate level, (ii) attenuated heart dysfunction with a higher left ventricular ejection fraction ( EF ), and (iii) promoted 48‐h survival of the rats compared to CLP animals with no melatonin treatment. In conclusion, our results show that rat myocardial mitochondrial Cc OX activity was depressed during severe sepsis accompanied by myocardial depression characterized by the decline of EF . In septic rats, melatonin increased the Cc OX activity, improved heart systolic function, and lowered mortality rate. The clinical use of melatonin in septic myocardial depression should be tested in the future." @default.
- W2036691084 created "2016-06-24" @default.
- W2036691084 creator A5001884955 @default.
- W2036691084 creator A5004491347 @default.
- W2036691084 creator A5025407969 @default.
- W2036691084 creator A5025851882 @default.
- W2036691084 creator A5049005863 @default.
- W2036691084 creator A5049409368 @default.
- W2036691084 creator A5073744778 @default.
- W2036691084 creator A5080272499 @default.
- W2036691084 creator A5085775357 @default.
- W2036691084 creator A5087768293 @default.
- W2036691084 date "2013-01-17" @default.
- W2036691084 modified "2023-10-13" @default.
- W2036691084 title "Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury" @default.
- W2036691084 cites W1485256456 @default.
- W2036691084 cites W1603480642 @default.
- W2036691084 cites W1607630441 @default.
- W2036691084 cites W1826003894 @default.
- W2036691084 cites W1913002361 @default.
- W2036691084 cites W1933021800 @default.
- W2036691084 cites W1946896925 @default.
- W2036691084 cites W1970991763 @default.
- W2036691084 cites W1983389892 @default.
- W2036691084 cites W1992507257 @default.
- W2036691084 cites W2010568558 @default.
- W2036691084 cites W2016808620 @default.
- W2036691084 cites W2025700695 @default.
- W2036691084 cites W2029078679 @default.
- W2036691084 cites W2029619625 @default.
- W2036691084 cites W2038285325 @default.
- W2036691084 cites W2045993202 @default.
- W2036691084 cites W2056256216 @default.
- W2036691084 cites W2071435303 @default.
- W2036691084 cites W2072950045 @default.
- W2036691084 cites W2074983056 @default.
- W2036691084 cites W2076849320 @default.
- W2036691084 cites W2091365164 @default.
- W2036691084 cites W2102747074 @default.
- W2036691084 cites W2129099976 @default.
- W2036691084 cites W2129434699 @default.
- W2036691084 cites W2142449302 @default.
- W2036691084 cites W2153819921 @default.
- W2036691084 cites W2157101465 @default.
- W2036691084 cites W2164334584 @default.
- W2036691084 cites W2167772881 @default.
- W2036691084 cites W2395559826 @default.
- W2036691084 cites W4244853473 @default.
- W2036691084 cites W4247000632 @default.
- W2036691084 cites W4252645959 @default.
- W2036691084 doi "https://doi.org/10.1111/jpi.12033" @default.
- W2036691084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23330702" @default.
- W2036691084 hasPublicationYear "2013" @default.
- W2036691084 type Work @default.
- W2036691084 sameAs 2036691084 @default.
- W2036691084 citedByCount "55" @default.
- W2036691084 countsByYear W20366910842013 @default.
- W2036691084 countsByYear W20366910842014 @default.
- W2036691084 countsByYear W20366910842015 @default.
- W2036691084 countsByYear W20366910842016 @default.
- W2036691084 countsByYear W20366910842017 @default.
- W2036691084 countsByYear W20366910842018 @default.
- W2036691084 countsByYear W20366910842019 @default.
- W2036691084 countsByYear W20366910842020 @default.
- W2036691084 countsByYear W20366910842021 @default.
- W2036691084 countsByYear W20366910842022 @default.
- W2036691084 countsByYear W20366910842023 @default.
- W2036691084 crossrefType "journal-article" @default.
- W2036691084 hasAuthorship W2036691084A5001884955 @default.
- W2036691084 hasAuthorship W2036691084A5004491347 @default.
- W2036691084 hasAuthorship W2036691084A5025407969 @default.
- W2036691084 hasAuthorship W2036691084A5025851882 @default.
- W2036691084 hasAuthorship W2036691084A5049005863 @default.
- W2036691084 hasAuthorship W2036691084A5049409368 @default.
- W2036691084 hasAuthorship W2036691084A5073744778 @default.
- W2036691084 hasAuthorship W2036691084A5080272499 @default.
- W2036691084 hasAuthorship W2036691084A5085775357 @default.
- W2036691084 hasAuthorship W2036691084A5087768293 @default.
- W2036691084 hasConcept C111566952 @default.
- W2036691084 hasConcept C126322002 @default.
- W2036691084 hasConcept C134018914 @default.
- W2036691084 hasConcept C164705383 @default.
- W2036691084 hasConcept C2776151105 @default.
- W2036691084 hasConcept C2777628635 @default.
- W2036691084 hasConcept C2777953023 @default.
- W2036691084 hasConcept C2778182776 @default.
- W2036691084 hasConcept C2778198053 @default.
- W2036691084 hasConcept C2778384902 @default.
- W2036691084 hasConcept C28859421 @default.
- W2036691084 hasConcept C55493867 @default.
- W2036691084 hasConcept C71924100 @default.
- W2036691084 hasConcept C78085059 @default.
- W2036691084 hasConcept C84393581 @default.
- W2036691084 hasConcept C86803240 @default.
- W2036691084 hasConceptScore W2036691084C111566952 @default.
- W2036691084 hasConceptScore W2036691084C126322002 @default.
- W2036691084 hasConceptScore W2036691084C134018914 @default.
- W2036691084 hasConceptScore W2036691084C164705383 @default.