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• W2036691655 startingPage "353" @default.
• W2036691655 abstract "X-irradiation has been used in the treatment of several human diseases, including AIDS-related-malignancies. X-irradiation might induce the transcription and the replication of human immunodeficiency virus type 1 (HIV-1) and enhance nuclear factor kappa B (NF-κB). In the present article we show that the activation of the HIV-1 long terminal repeat (LTR) by direct X-irradiation can be mimicked by coculture of transfected cells with X-irradiated nontransfected (HIV-1-negative) cells. In the human colonic carcinoma cell line HT29, the activation seems to depend on an extracellular factor(s) released by a cell line treated with X-rays. The HIV-1 LTR cis-acting element conferring X-indirect responsiveness was identified as the κB tandem motif. The two main nuclear HIV-1 κB-binding complexes activated by X-direct and -indirect irradiation were the NF-κB p50/p65 and c-Rel/p65 heterodimers. Nuclear NF-κB activation was dependent on protein neosynthesis. It was partially inhibited by 100 μM pyrrolidine dithiocarbamate, a potent antioxidant drug, but was not correlated with a significant decrease in cellular IκBα. Furthermore, X-irradiation induces the expression of several cytokine genes generally associated with stress response and antibodies against interleukin 6 and TNF-α partially inhibited the X-indirect activation of the HIV-1 LTR. The use of protein kinase C (PKC)-specific inhibitor and of forskolin, an adenylate cyclase activator, suggests that a PKC-dependent pathway and the cAMP intracellular concentration could play a role in the X-indirect enhancement of HIV-1 LTR transcription in the HT29 cell line. In addition, supernatants of an X-irradiated HT29 cell culture activated the HIV-1 stimulation in infected peripheral blood monocytes." @default.
• W2036691655 created "2016-06-24" @default.
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• W2036691655 date "1998-03-01" @default.
• W2036691655 modified "2023-10-18" @default.
• W2036691655 title "Secretion of Extracellular Factor(s) Induced by X-Irradiation Activates the HIV Type 1 Long Terminal Repeat through Its κB Motif" @default.
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• W2036691655 doi "https://doi.org/10.1089/aid.1998.14.353" @default.
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