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• W2036691914 abstract "Background: Neonatal mortality and morbidity are gender-biased in low-birth-weight (LBW) infants. The male disadvantage theory has been suggested to be responsible for these maturational differences. Objective: To examine the impact of gender on neonatal hyperbilirubinemia. Design/Methods: A retrospective observational study. Data on all LBW infants admitted to George Washington University neonatal intensive care unit and surviving for >48 hrs from January 1992 to March 2003 were analyzed. Males and females were compared for gestational age, birth weight, race, Apgar scores at 1 and 5 mins, peak bilirubin levels, sepsis, and intraventricular hemorrhage (IVH). Significant differences were entered in a regression model to detect the influence of gender on bilirubin (Bili). Analysis was repeated after stratification of infants into: group A, <1000 g; group B, 1000–1499 g; and group C, 1500–2499 g. Results: A total of 840 infants were included in this study. When comparing males (n = 407) with females (n = 433), significant differences were detected in birth weight (1,539 ± 541 vs. 1,428 ± 549 g; p = .003), IVH (14.2% vs. 9%; p = .025), and Bili (10.1 ± 3.0 vs. 9.2 ± 2.8 mg%; p < .001). No differences were detected in gestational age, sepsis, or Apgar 1 and 5. Difference in Bili for the entire group remained significant in the regression model (regression coefficient [RC] = 0.79 ± 0.22; p < .001). In subgroup analyses: group A Bili (8.4 ± 2.3 vs. 8.0 ± 2.0; p = .14) and group B Bili (9.0 ± 2.1 vs. 9.2 ± 2.2; p = .51) did not differ in bivariate or multivariate analyses. In group C, Bili was (11.3 ± 3.1 vs. 10.1 ± 3.3; p < .001) and remained the only significant difference in the regression model (RC = 1.19 ± 0.37; p = .001). Conclusions: Bili in LBW infants is significantly higher in males when compared with females. After stratification to birth weight subgroups, significance is retained in the 1500- to 2499-g group after logistic regression analysis. Bili levels in infants <1500 g are influenced more significantly by factors other than gender, such as sepsis and IVH." @default.
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• W2036691914 date "2005-03-01" @default.
• W2036691914 modified "2023-09-23" @default.
• W2036691914 title "Does gender affect neonatal hyperbilirubinemia in low-birth-weight infants?" @default.
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• W2036691914 doi "https://doi.org/10.1097/01.pcc.0000154961.37833.79" @default.
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