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- W2036692093 abstract "The effect of triiodothyronine on the activity and amount of the key lipogenic enzyme fatty acid synthetase was studied in differentiating preadipocyte cells (ob 17 ) isolated from ob/ob mouse epididymal fat pad. In the presence of physiological concentrations of insulin, the acquisition of adipose morphology was accompanied by a parallel increase (10–15-fold) in synthetase specific activity and radioimmunoassayable amount relative to soluble cellular proteins. Inclusion of T 3 at confluence significantly enhanced synthetase activity and content, with a maximum of 1.5–2-fold above controls at the physiological 1.5 nM concentration, whether insulin is present or not. During adipose conversion, T 3 increased the development of enzyme activity and, after a longer lag period, the accumulation of the synthetase. Our results suggest that the stimulating effect of T 3 upon synthetase activity could involve as a first step the activation of preexisting inactive synthetase molecules and as a second one an increased accumulation of activable synthetase. After longer culture periods, inactive radioimmunoassayable synthetase accumulated." @default.
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- W2036692093 date "1983-02-01" @default.
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- W2036692093 title "The effect of triiodothyronine on fatty acid synthetase activity and content in differentiating ob17 preadipocytes" @default.
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- W2036692093 doi "https://doi.org/10.1016/0005-2760(83)90030-9" @default.
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