Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036692336> ?p ?o ?g. }
- W2036692336 endingPage "997" @default.
- W2036692336 startingPage "997" @default.
- W2036692336 abstract "During spermatogenesis, approximately 85% of histones are replaced by protamines. The remaining histones have been proposed to carry essential marks for the establishment of epigenetic information in the offspring. The aim of the present study was to analyse the expression pattern of histone H3 acetylated at lysine 9 (H3K9ac) during normal and impaired spermatogenesis and the binding pattern of H3K9ac to selected genes within ejaculates. Testicular biopsies, as well as semen samples, were used for immunohistochemistry. Chromatin immunoprecipitation was performed with ejaculated sperm chromatin. HeLa cells and prostate tissue served as controls. Binding of selected genes was evaluated by semiquantitative and real-time polymerase chain reaction. Immunohistochemistry of H3K9ac demonstrated positive signals in spermatogonia, spermatocytes, elongating spermatids and ejaculated spermatozoa of fertile and infertile men. H3K9ac was associated with gene promoters (CRAT, G6PD, MCF2L), exons (SOX2, GAPDH, STK11IP, FLNA, PLXNA3, SH3GLB2, CTSD) and intergenic regions (TH) in fertile men and revealed shifts of the distribution pattern in ejaculated spermatozoa of infertile men. In conclusion, H3K9ac is present in male germ cells and may play a role during the development of human spermatozoa. In addition, H3K9ac is associated with specific regions of the sperm genome defining an epigenetic code that may influence gene expression directly after fertilisation." @default.
- W2036692336 created "2016-06-24" @default.
- W2036692336 creator A5010732653 @default.
- W2036692336 creator A5015496755 @default.
- W2036692336 creator A5019770940 @default.
- W2036692336 creator A5020892711 @default.
- W2036692336 creator A5025101056 @default.
- W2036692336 creator A5027202068 @default.
- W2036692336 creator A5040216646 @default.
- W2036692336 creator A5055275116 @default.
- W2036692336 creator A5064995734 @default.
- W2036692336 date "2011-01-01" @default.
- W2036692336 modified "2023-09-26" @default.
- W2036692336 title "Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa" @default.
- W2036692336 cites W1487878375 @default.
- W2036692336 cites W1874007049 @default.
- W2036692336 cites W1921479150 @default.
- W2036692336 cites W1964923286 @default.
- W2036692336 cites W1969691479 @default.
- W2036692336 cites W1972439760 @default.
- W2036692336 cites W1975905048 @default.
- W2036692336 cites W1976300935 @default.
- W2036692336 cites W1976381338 @default.
- W2036692336 cites W1978104691 @default.
- W2036692336 cites W1979449471 @default.
- W2036692336 cites W1983861034 @default.
- W2036692336 cites W1992774399 @default.
- W2036692336 cites W2003183164 @default.
- W2036692336 cites W2007367058 @default.
- W2036692336 cites W2007973513 @default.
- W2036692336 cites W2009498922 @default.
- W2036692336 cites W2009714281 @default.
- W2036692336 cites W2012612933 @default.
- W2036692336 cites W2013745227 @default.
- W2036692336 cites W2014254198 @default.
- W2036692336 cites W2021779022 @default.
- W2036692336 cites W2027974804 @default.
- W2036692336 cites W2034207297 @default.
- W2036692336 cites W2037818631 @default.
- W2036692336 cites W2041482906 @default.
- W2036692336 cites W2042653686 @default.
- W2036692336 cites W2044254819 @default.
- W2036692336 cites W2047321973 @default.
- W2036692336 cites W2047469234 @default.
- W2036692336 cites W2049427939 @default.
- W2036692336 cites W2053508758 @default.
- W2036692336 cites W2054990893 @default.
- W2036692336 cites W2059482132 @default.
- W2036692336 cites W2059664494 @default.
- W2036692336 cites W2061487074 @default.
- W2036692336 cites W2065891506 @default.
- W2036692336 cites W2066206581 @default.
- W2036692336 cites W2068224188 @default.
- W2036692336 cites W2071364732 @default.
- W2036692336 cites W2075977131 @default.
- W2036692336 cites W2078661700 @default.
- W2036692336 cites W2083245183 @default.
- W2036692336 cites W2087237333 @default.
- W2036692336 cites W2088361508 @default.
- W2036692336 cites W2091275395 @default.
- W2036692336 cites W2096083625 @default.
- W2036692336 cites W2104768741 @default.
- W2036692336 cites W2105571228 @default.
- W2036692336 cites W2106058652 @default.
- W2036692336 cites W2106886154 @default.
- W2036692336 cites W2112913464 @default.
- W2036692336 cites W2114409266 @default.
- W2036692336 cites W2116111714 @default.
- W2036692336 cites W2128240046 @default.
- W2036692336 cites W2129328925 @default.
- W2036692336 cites W2133769516 @default.
- W2036692336 cites W2133938268 @default.
- W2036692336 cites W2134087142 @default.
- W2036692336 cites W2138760938 @default.
- W2036692336 cites W2144691110 @default.
- W2036692336 cites W2147452407 @default.
- W2036692336 cites W2148604738 @default.
- W2036692336 cites W2150994798 @default.
- W2036692336 cites W2152544605 @default.
- W2036692336 cites W2158747282 @default.
- W2036692336 cites W2159902645 @default.
- W2036692336 cites W2161827767 @default.
- W2036692336 cites W2163585426 @default.
- W2036692336 cites W2164089374 @default.
- W2036692336 cites W2167137510 @default.
- W2036692336 cites W2168831494 @default.
- W2036692336 doi "https://doi.org/10.1071/rd10197" @default.
- W2036692336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22127005" @default.
- W2036692336 hasPublicationYear "2011" @default.
- W2036692336 type Work @default.
- W2036692336 sameAs 2036692336 @default.
- W2036692336 citedByCount "41" @default.
- W2036692336 countsByYear W20366923362012 @default.
- W2036692336 countsByYear W20366923362013 @default.
- W2036692336 countsByYear W20366923362014 @default.
- W2036692336 countsByYear W20366923362015 @default.
- W2036692336 countsByYear W20366923362016 @default.
- W2036692336 countsByYear W20366923362017 @default.