Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036692499> ?p ?o ?g. }
- W2036692499 endingPage "233" @default.
- W2036692499 startingPage "225" @default.
- W2036692499 abstract "Although phosphoinositide 3-kinases (PI3-K) are known to participate in anti-apoptotic pathways, their importance in modulating neutrophil apoptosis in vivo has not been examined. In these studies, we used neutrophils from mice lacking the PI3-Kgamma isoform (PI3-Kgamma-/-) to determine the role that PI3-Kgamma occupies in neutrophil apoptosis under in vivo conditions. We found that neutrophil apoptosis under basal and LPS-stimulated conditions was increased in PI3-Kgamma-/- mice compared to that present in control PI3-Kgamma+/+ animals. Neutrophils from PI3-Kgamma-/- mice demonstrated decreased amounts of active, serine 473 phosphorylated Akt, phosphorylated CREB, and diminished nuclear translocation of NF-kappaB. Levels of the CREB-dependent anti-apoptotic protein Mcl-1 and of the NF-kappaB-dependent anti-apoptotic mediator Bcl-x(L) were significantly decreased in PI3-Kgamma-/- neutrophils. In contrast, PI3-Kgamma-/- neutrophils contained diminished amounts of phosphorylated, inactive forms of the pro-apoptotic mediators, Bad, FKHR, and GSK-3beta. These results demonstrate that PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis." @default.
- W2036692499 created "2016-06-24" @default.
- W2036692499 creator A5006578605 @default.
- W2036692499 creator A5008986006 @default.
- W2036692499 creator A5014333112 @default.
- W2036692499 creator A5023215362 @default.
- W2036692499 creator A5028690844 @default.
- W2036692499 creator A5053348907 @default.
- W2036692499 creator A5073287784 @default.
- W2036692499 creator A5086504706 @default.
- W2036692499 date "2003-02-01" @default.
- W2036692499 modified "2023-10-17" @default.
- W2036692499 title "Involvement of phosphatidylinositol 3-kinase γ in neutrophil apoptosis" @default.
- W2036692499 cites W12631990 @default.
- W2036692499 cites W1499902555 @default.
- W2036692499 cites W1511742236 @default.
- W2036692499 cites W1625966995 @default.
- W2036692499 cites W17050809 @default.
- W2036692499 cites W1891774658 @default.
- W2036692499 cites W1947823487 @default.
- W2036692499 cites W1975290731 @default.
- W2036692499 cites W1979012323 @default.
- W2036692499 cites W1981936226 @default.
- W2036692499 cites W1990841830 @default.
- W2036692499 cites W1993216157 @default.
- W2036692499 cites W1993342205 @default.
- W2036692499 cites W2002127663 @default.
- W2036692499 cites W2005732248 @default.
- W2036692499 cites W2015788325 @default.
- W2036692499 cites W2016129444 @default.
- W2036692499 cites W2023472659 @default.
- W2036692499 cites W2024880806 @default.
- W2036692499 cites W2027042060 @default.
- W2036692499 cites W2030573603 @default.
- W2036692499 cites W2049243219 @default.
- W2036692499 cites W2051219590 @default.
- W2036692499 cites W2053265248 @default.
- W2036692499 cites W2053305914 @default.
- W2036692499 cites W2061440101 @default.
- W2036692499 cites W2067505285 @default.
- W2036692499 cites W2080128214 @default.
- W2036692499 cites W2088472722 @default.
- W2036692499 cites W2101840637 @default.
- W2036692499 cites W2127081597 @default.
- W2036692499 cites W2127997433 @default.
- W2036692499 cites W2130594577 @default.
- W2036692499 cites W2135487116 @default.
- W2036692499 cites W2137035181 @default.
- W2036692499 cites W2137904098 @default.
- W2036692499 cites W2147114673 @default.
- W2036692499 cites W2150110104 @default.
- W2036692499 cites W2151313755 @default.
- W2036692499 cites W2158092127 @default.
- W2036692499 cites W2163579392 @default.
- W2036692499 cites W2166655452 @default.
- W2036692499 cites W2169724245 @default.
- W2036692499 cites W43460215 @default.
- W2036692499 doi "https://doi.org/10.1016/s0898-6568(02)00063-3" @default.
- W2036692499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12464394" @default.
- W2036692499 hasPublicationYear "2003" @default.
- W2036692499 type Work @default.
- W2036692499 sameAs 2036692499 @default.
- W2036692499 citedByCount "50" @default.
- W2036692499 countsByYear W20366924992012 @default.
- W2036692499 countsByYear W20366924992013 @default.
- W2036692499 countsByYear W20366924992014 @default.
- W2036692499 countsByYear W20366924992015 @default.
- W2036692499 countsByYear W20366924992017 @default.
- W2036692499 countsByYear W20366924992018 @default.
- W2036692499 countsByYear W20366924992019 @default.
- W2036692499 countsByYear W20366924992021 @default.
- W2036692499 countsByYear W20366924992023 @default.
- W2036692499 crossrefType "journal-article" @default.
- W2036692499 hasAuthorship W2036692499A5006578605 @default.
- W2036692499 hasAuthorship W2036692499A5008986006 @default.
- W2036692499 hasAuthorship W2036692499A5014333112 @default.
- W2036692499 hasAuthorship W2036692499A5023215362 @default.
- W2036692499 hasAuthorship W2036692499A5028690844 @default.
- W2036692499 hasAuthorship W2036692499A5053348907 @default.
- W2036692499 hasAuthorship W2036692499A5073287784 @default.
- W2036692499 hasAuthorship W2036692499A5086504706 @default.
- W2036692499 hasConcept C104317684 @default.
- W2036692499 hasConcept C11960822 @default.
- W2036692499 hasConcept C153911025 @default.
- W2036692499 hasConcept C1629964 @default.
- W2036692499 hasConcept C184235292 @default.
- W2036692499 hasConcept C185592680 @default.
- W2036692499 hasConcept C190283241 @default.
- W2036692499 hasConcept C207001950 @default.
- W2036692499 hasConcept C2780610907 @default.
- W2036692499 hasConcept C54355233 @default.
- W2036692499 hasConcept C55493867 @default.
- W2036692499 hasConcept C62478195 @default.
- W2036692499 hasConcept C75217442 @default.
- W2036692499 hasConcept C86339819 @default.
- W2036692499 hasConcept C86803240 @default.
- W2036692499 hasConcept C95444343 @default.
- W2036692499 hasConceptScore W2036692499C104317684 @default.