FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036692598> ?p ?o ?g. }

• W2036692598 endingPage "1469" @default.
• W2036692598 startingPage "1463" @default.
• W2036692598 abstract "The DNA binding specificities of CREB1 and CREB2 homodimers and the CREB2/cJun heterodimer were analyzed with a CASTing technique. All but one of the selected sequences varied from the consensus CRE (TGACGTCA) by three nucleotides or less. The profile of variations selected and the binding affinity for these sequences were unique for each CREB complex. The affinities were not effected by the palindromic nature of the sequences, but were strongly effected by flanking sequences. The strength of DNA binding in vitro correlated with the degree of transactivation observed in JEG-3 cells transfected with reporter plasmids harboring CRE variants, when hybrid CREB proteins fused to the VP16 activation domain were expressed. When native CREB proteins were expressed, the correlation was attenuated by the nature of the variant sequence. A CRE variant (TGACATCA) found in several natural promoters, exhibited the lowest basal transcription rate of the variants and a lower level of induction than expected when compared with the in vitro binding data. These results indicate that transactivation of DNA sequence elements is strongly effected by the strength of transcription factor binding, and that individual sequences can attenuate the level of induction." @default.
• W2036692598 created "2016-06-24" @default.
• W2036692598 creator A5076196099 @default.
• W2036692598 creator A5076769617 @default.
• W2036692598 date "1994-01-01" @default.
• W2036692598 modified "2023-09-26" @default.
• W2036692598 title "Different binding specificities and transactivation of variant CRE's by CREB complexes" @default.
• W2036692598 cites W1495237614 @default.
• W2036692598 cites W1543803803 @default.
• W2036692598 cites W1549983991 @default.
• W2036692598 cites W1557042258 @default.
• W2036692598 cites W1564556915 @default.
• W2036692598 cites W1574327030 @default.
• W2036692598 cites W1587727602 @default.
• W2036692598 cites W1604033113 @default.
• W2036692598 cites W1748230350 @default.
• W2036692598 cites W1887488204 @default.
• W2036692598 cites W1902926467 @default.
• W2036692598 cites W1926945023 @default.
• W2036692598 cites W1951047070 @default.
• W2036692598 cites W1958327809 @default.
• W2036692598 cites W1967004332 @default.
• W2036692598 cites W1967653587 @default.
• W2036692598 cites W1974034312 @default.
• W2036692598 cites W1979647722 @default.
• W2036692598 cites W1982598173 @default.
• W2036692598 cites W1985603777 @default.
• W2036692598 cites W1992289621 @default.
• W2036692598 cites W1995136152 @default.
• W2036692598 cites W1996339709 @default.
• W2036692598 cites W2000024512 @default.
• W2036692598 cites W2000324336 @default.
• W2036692598 cites W2000371106 @default.
• W2036692598 cites W2006659499 @default.
• W2036692598 cites W2015733063 @default.
• W2036692598 cites W2020257254 @default.
• W2036692598 cites W2022478055 @default.
• W2036692598 cites W2023666553 @default.
• W2036692598 cites W2028242823 @default.
• W2036692598 cites W2040328923 @default.
• W2036692598 cites W2041802997 @default.
• W2036692598 cites W2067531311 @default.
• W2036692598 cites W2067837253 @default.
• W2036692598 cites W2071500474 @default.
• W2036692598 cites W2074568047 @default.
• W2036692598 cites W2077088537 @default.
• W2036692598 cites W2081704409 @default.
• W2036692598 cites W2089372467 @default.
• W2036692598 cites W2090119499 @default.
• W2036692598 cites W2091197992 @default.
• W2036692598 cites W2094807913 @default.
• W2036692598 cites W2109399660 @default.
• W2036692598 cites W2111393771 @default.
• W2036692598 cites W2112343652 @default.
• W2036692598 cites W2136210811 @default.
• W2036692598 cites W2141677833 @default.
• W2036692598 cites W2144127992 @default.
• W2036692598 cites W2342346004 @default.
• W2036692598 cites W2406805804 @default.
• W2036692598 cites W2409292871 @default.
• W2036692598 cites W2417732733 @default.
• W2036692598 cites W2418007510 @default.
• W2036692598 cites W2461415929 @default.
• W2036692598 cites W2469779349 @default.
• W2036692598 cites W904109129 @default.
• W2036692598 doi "https://doi.org/10.1093/nar/22.8.1463" @default.
• W2036692598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/308006" @default.
• W2036692598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8190638" @default.
• W2036692598 hasPublicationYear "1994" @default.
• W2036692598 type Work @default.
• W2036692598 sameAs 2036692598 @default.
• W2036692598 citedByCount "137" @default.
• W2036692598 countsByYear W20366925982012 @default.
• W2036692598 countsByYear W20366925982013 @default.
• W2036692598 countsByYear W20366925982015 @default.
• W2036692598 countsByYear W20366925982016 @default.
• W2036692598 countsByYear W20366925982018 @default.
• W2036692598 countsByYear W20366925982020 @default.
• W2036692598 countsByYear W20366925982023 @default.
• W2036692598 crossrefType "journal-article" @default.
• W2036692598 hasAuthorship W2036692598A5076196099 @default.
• W2036692598 hasAuthorship W2036692598A5076769617 @default.
• W2036692598 hasBestOaLocation W20366925982 @default.
• W2036692598 hasConcept C101762097 @default.
• W2036692598 hasConcept C104317684 @default.
• W2036692598 hasConcept C107824862 @default.
• W2036692598 hasConcept C1292079 @default.
• W2036692598 hasConcept C132376346 @default.
• W2036692598 hasConcept C138885662 @default.
• W2036692598 hasConcept C141231307 @default.
• W2036692598 hasConcept C150194340 @default.
• W2036692598 hasConcept C153911025 @default.
• W2036692598 hasConcept C1629964 @default.
• W2036692598 hasConcept C179926584 @default.
• W2036692598 hasConcept C3662595 @default.
• W2036692598 hasConcept C41895202 @default.
• W2036692598 hasConcept C44667518 @default.
• W2036692598 hasConcept C54355233 @default.

• next