Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036692879> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2036692879 endingPage "747" @default.
- W2036692879 startingPage "743" @default.
- W2036692879 abstract "It is unknown whether two smaller doses of oral transmucosal fentanyl citrate (OTFC) administered simultaneously are pharmacokinetically equivalent to an identical dose administered as a single unit. This issue has important practical implications when patients are attempting to identify the appropriate dosage of OTFC to control their pain. This open-label, randomized, crossover design study compared the pharmacokinetics of two simultaneously consumed 400 microg OTFC doses with one 800 microg OTFC dose in 12 healthy volunteers. The two treatments were pharmacokinetically equivalent. The maximum concentration produced for each dosage group (Cmax) was 1.09 ng/ml for two 400 microg dose and 1.10 ng/ml for one 800 microg dose. Area under the curve (AUC) was 8.2 ng/ml.hr (SE=1.1) and 7.2 ng/ml.hr (SE=1.0). There were no significant differences between the treatment groups in either the time to peak concentration (Tmax) or the mean residence time (MRT). The results demonstrate the bioequivalence of two 400 microg with one 800 microg OTFC units." @default.
- W2036692879 created "2016-06-24" @default.
- W2036692879 creator A5007415488 @default.
- W2036692879 creator A5014253211 @default.
- W2036692879 creator A5045218676 @default.
- W2036692879 creator A5047172246 @default.
- W2036692879 date "2003-08-01" @default.
- W2036692879 modified "2023-10-13" @default.
- W2036692879 title "A Pharmacokinetic Study to Compare Two Simultaneous 400 μg Doses with a Single 800 μg Dose of Oral Transmucosal Fentanyl Citrate" @default.
- W2036692879 cites W1976427793 @default.
- W2036692879 cites W2008275924 @default.
- W2036692879 cites W2028222258 @default.
- W2036692879 cites W2036094245 @default.
- W2036692879 cites W2075716831 @default.
- W2036692879 cites W2154719748 @default.
- W2036692879 doi "https://doi.org/10.1016/s0885-3924(03)00241-0" @default.
- W2036692879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12906959" @default.
- W2036692879 hasPublicationYear "2003" @default.
- W2036692879 type Work @default.
- W2036692879 sameAs 2036692879 @default.
- W2036692879 citedByCount "26" @default.
- W2036692879 countsByYear W20366928792012 @default.
- W2036692879 countsByYear W20366928792013 @default.
- W2036692879 countsByYear W20366928792015 @default.
- W2036692879 countsByYear W20366928792018 @default.
- W2036692879 countsByYear W20366928792020 @default.
- W2036692879 countsByYear W20366928792023 @default.
- W2036692879 crossrefType "journal-article" @default.
- W2036692879 hasAuthorship W2036692879A5007415488 @default.
- W2036692879 hasAuthorship W2036692879A5014253211 @default.
- W2036692879 hasAuthorship W2036692879A5045218676 @default.
- W2036692879 hasAuthorship W2036692879A5047172246 @default.
- W2036692879 hasBestOaLocation W20366928791 @default.
- W2036692879 hasConcept C112705442 @default.
- W2036692879 hasConcept C142724271 @default.
- W2036692879 hasConcept C204787440 @default.
- W2036692879 hasConcept C22979827 @default.
- W2036692879 hasConcept C27081682 @default.
- W2036692879 hasConcept C2781072394 @default.
- W2036692879 hasConcept C42219234 @default.
- W2036692879 hasConcept C42404028 @default.
- W2036692879 hasConcept C71924100 @default.
- W2036692879 hasConcept C87813604 @default.
- W2036692879 hasConcept C98274493 @default.
- W2036692879 hasConceptScore W2036692879C112705442 @default.
- W2036692879 hasConceptScore W2036692879C142724271 @default.
- W2036692879 hasConceptScore W2036692879C204787440 @default.
- W2036692879 hasConceptScore W2036692879C22979827 @default.
- W2036692879 hasConceptScore W2036692879C27081682 @default.
- W2036692879 hasConceptScore W2036692879C2781072394 @default.
- W2036692879 hasConceptScore W2036692879C42219234 @default.
- W2036692879 hasConceptScore W2036692879C42404028 @default.
- W2036692879 hasConceptScore W2036692879C71924100 @default.
- W2036692879 hasConceptScore W2036692879C87813604 @default.
- W2036692879 hasConceptScore W2036692879C98274493 @default.
- W2036692879 hasIssue "2" @default.
- W2036692879 hasLocation W20366928791 @default.
- W2036692879 hasLocation W20366928792 @default.
- W2036692879 hasOpenAccess W2036692879 @default.
- W2036692879 hasPrimaryLocation W20366928791 @default.
- W2036692879 hasRelatedWork W1506722149 @default.
- W2036692879 hasRelatedWork W1984778235 @default.
- W2036692879 hasRelatedWork W2008610508 @default.
- W2036692879 hasRelatedWork W2033685750 @default.
- W2036692879 hasRelatedWork W2055974197 @default.
- W2036692879 hasRelatedWork W2102441621 @default.
- W2036692879 hasRelatedWork W2104641112 @default.
- W2036692879 hasRelatedWork W2359939078 @default.
- W2036692879 hasRelatedWork W2374464808 @default.
- W2036692879 hasRelatedWork W2611950068 @default.
- W2036692879 hasVolume "26" @default.
- W2036692879 isParatext "false" @default.
- W2036692879 isRetracted "false" @default.
- W2036692879 magId "2036692879" @default.
- W2036692879 workType "article" @default.