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- W2036694766 abstract "In order to test the role of mu and kappa opioid receptors (Mu opioid receptor (MOR) and Kappa opioid receptor (KOR)) in hippocampal‐dependent spatial learning, we analyzed genetically engineered null mutant mice missing the functional MOR or KOR gene. Compared to wild‐type mice, the homozygous MOR null mutants exhibited an impairment in the ultimate level of spatial learning as shown in two distinct tasks, the 8‐arm radial‐maze and the Morris water‐maze. Control behaviors were normal. The learning impairment could be associated with the impairment we found in the maintenance of long‐term potentiation in mossy fibers in CA3. In comparison, there was no impairment in spatial learning in our KOR mutants or in mossy fibers (mf) in CA3 region long‐term potentiation (LTP). Our work suggests that the MOR may play a positive role in learning and memory by increasing LTP in CA3 neurons." @default.
- W2036694766 created "2016-06-24" @default.
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- W2036694766 date "2003-03-21" @default.
- W2036694766 modified "2023-10-15" @default.
- W2036694766 title "Differential involvement of the Mu and Kappa opioid receptors in spatial learning" @default.
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- W2036694766 doi "https://doi.org/10.1034/j.1601-183x.2003.00013.x" @default.
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