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• W2036694934 abstract "Mast cell proteases play an important role in the regulation of the immune response. We identified the cDNA of the mast cell protease 8 (MCP-8) gene and analyzed its genomic structure in tilapia. The ORF of the MCP-8 was 768 bp, encoding 255 amino acids. Quantitative real-time PCR revealed that the MCP-8 gene was expressed predominantly in spleen, moderately in liver, blood, brain, gill, intestine, skin, and weakly expressed in kidney, muscle and eye. After a challenge with Streptococcus agalactiae, the gene was induced significantly (p < 0.05) in intestine, kidney, spleen and liver. Furthermore, we identified five single nucleotide polymorphisms (SNPs) in the MCP-8 gene and found that three SNPs were significantly associated (p < 0.05) with resistance against S. agalactiae. However, we found no association between four SNPs and growth traits (p > 0.05). These results suggest that the MCP-8 gene play an important role in the resistance to S. agalactiae in tilapia. The SNP markers in the MCP-8 gene associated with the resistance to the bacterial pathogen may facilitate selection of tilapia resistant to the bacterial disease." @default.
• W2036694934 created "2016-06-24" @default.
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• W2036694934 date "2014-09-01" @default.
• W2036694934 modified "2023-09-26" @default.
• W2036694934 title "The MCP-8 gene and its possible association with resistance to Streptococcus agalactiae in tilapia" @default.
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• W2036694934 doi "https://doi.org/10.1016/j.fsi.2014.07.019" @default.
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• W2036694934 hasPublicationYear "2014" @default.
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