FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036697594> ?p ?o ?g. }

• W2036697594 endingPage "130" @default.
• W2036697594 startingPage "126" @default.
• W2036697594 abstract "Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered an important enzyme contributing to the pathogenesis of persistent pain. The aim of this study was to test whether intrathecal injection of CaMKII inhibitors may reduce pain-related behavior in diabetic rats. Male Sprague-Dawley rats were used. Diabetes was induced with intraperitoneal injection of 55mg/kg streptozotocin. Two weeks after diabetes induction, CaMKII inhibitor myristoil-AIP or KN-93 was injected intrathecally. Behavioral testing with mechanical and thermal stimuli was performed before induction of diabetes, the day preceding the injection, as well as 2h and 24h after the intrathecal injection. The expression of total CaMKII and its alpha isoform in dorsal horn was quantified using immunohistochemistry. Intrathecal injection of mAIP and KN-93 resulted in significant decrease in expression of total CaMKII and CaMKII alpha isoform activity. Also, mAIP and KN93 injection significantly increased sensitivity to a mechanical stimulus 24h after i.t. injection. Intrathecal inhibition of CaMKII reduced the expression of total CaMKII and its CaMKII alpha isoform activity in diabetic dorsal horn, which was accompanied with an increase in pain-related behavior. Further studies about the intrathecal inhibition of CaMKII should elucidate its role in nociceptive processes of diabetic neuropathy." @default.
• W2036697594 created "2016-06-24" @default.
• W2036697594 creator A5008533614 @default.
• W2036697594 creator A5034585629 @default.
• W2036697594 creator A5049985810 @default.
• W2036697594 creator A5063971161 @default.
• W2036697594 creator A5069531413 @default.
• W2036697594 creator A5082984190 @default.
• W2036697594 date "2013-10-01" @default.
• W2036697594 modified "2023-09-27" @default.
• W2036697594 title "Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior" @default.
• W2036697594 cites W1581414031 @default.
• W2036697594 cites W1984926856 @default.
• W2036697594 cites W1991245942 @default.
• W2036697594 cites W1991406619 @default.
• W2036697594 cites W2003191908 @default.
• W2036697594 cites W2008800359 @default.
• W2036697594 cites W2009905731 @default.
• W2036697594 cites W2014670473 @default.
• W2036697594 cites W2028307723 @default.
• W2036697594 cites W2032302528 @default.
• W2036697594 cites W2033841060 @default.
• W2036697594 cites W2041272952 @default.
• W2036697594 cites W2050199100 @default.
• W2036697594 cites W2055454317 @default.
• W2036697594 cites W2056481979 @default.
• W2036697594 cites W2067008987 @default.
• W2036697594 cites W2077392459 @default.
• W2036697594 cites W2078011416 @default.
• W2036697594 cites W2091103694 @default.
• W2036697594 cites W2094437785 @default.
• W2036697594 cites W2098015915 @default.
• W2036697594 cites W2102504608 @default.
• W2036697594 cites W2116938598 @default.
• W2036697594 cites W2128690456 @default.
• W2036697594 cites W2139163490 @default.
• W2036697594 cites W2139215160 @default.
• W2036697594 cites W2140910583 @default.
• W2036697594 cites W2142105530 @default.
• W2036697594 cites W2147111904 @default.
• W2036697594 cites W2151241130 @default.
• W2036697594 cites W4213379388 @default.
• W2036697594 doi "https://doi.org/10.1016/j.neulet.2013.09.002" @default.
• W2036697594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24035897" @default.
• W2036697594 hasPublicationYear "2013" @default.
• W2036697594 type Work @default.
• W2036697594 sameAs 2036697594 @default.
• W2036697594 citedByCount "7" @default.
• W2036697594 countsByYear W20366975942014 @default.
• W2036697594 countsByYear W20366975942017 @default.
• W2036697594 countsByYear W20366975942022 @default.
• W2036697594 countsByYear W20366975942023 @default.
• W2036697594 crossrefType "journal-article" @default.
• W2036697594 hasAuthorship W2036697594A5008533614 @default.
• W2036697594 hasAuthorship W2036697594A5034585629 @default.
• W2036697594 hasAuthorship W2036697594A5049985810 @default.
• W2036697594 hasAuthorship W2036697594A5063971161 @default.
• W2036697594 hasAuthorship W2036697594A5069531413 @default.
• W2036697594 hasAuthorship W2036697594A5082984190 @default.
• W2036697594 hasConcept C126322002 @default.
• W2036697594 hasConcept C134018914 @default.
• W2036697594 hasConcept C15490471 @default.
• W2036697594 hasConcept C170493617 @default.
• W2036697594 hasConcept C2777107010 @default.
• W2036697594 hasConcept C2779178840 @default.
• W2036697594 hasConcept C2779280383 @default.
• W2036697594 hasConcept C2780159080 @default.
• W2036697594 hasConcept C519063684 @default.
• W2036697594 hasConcept C555293320 @default.
• W2036697594 hasConcept C71924100 @default.
• W2036697594 hasConcept C98274493 @default.
• W2036697594 hasConceptScore W2036697594C126322002 @default.
• W2036697594 hasConceptScore W2036697594C134018914 @default.
• W2036697594 hasConceptScore W2036697594C15490471 @default.
• W2036697594 hasConceptScore W2036697594C170493617 @default.
• W2036697594 hasConceptScore W2036697594C2777107010 @default.
• W2036697594 hasConceptScore W2036697594C2779178840 @default.
• W2036697594 hasConceptScore W2036697594C2779280383 @default.
• W2036697594 hasConceptScore W2036697594C2780159080 @default.
• W2036697594 hasConceptScore W2036697594C519063684 @default.
• W2036697594 hasConceptScore W2036697594C555293320 @default.
• W2036697594 hasConceptScore W2036697594C71924100 @default.
• W2036697594 hasConceptScore W2036697594C98274493 @default.
• W2036697594 hasLocation W20366975941 @default.
• W2036697594 hasLocation W20366975942 @default.
• W2036697594 hasOpenAccess W2036697594 @default.
• W2036697594 hasPrimaryLocation W20366975941 @default.
• W2036697594 hasRelatedWork W1995071802 @default.
• W2036697594 hasRelatedWork W2004012005 @default.
• W2036697594 hasRelatedWork W2011709829 @default.
• W2036697594 hasRelatedWork W2055342276 @default.
• W2036697594 hasRelatedWork W2080996905 @default.
• W2036697594 hasRelatedWork W2092993950 @default.
• W2036697594 hasRelatedWork W2095626059 @default.
• W2036697594 hasRelatedWork W2140892006 @default.
• W2036697594 hasRelatedWork W2158125198 @default.
• W2036697594 hasRelatedWork W2380317211 @default.
• W2036697594 hasVolume "554" @default.

• next