FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036697637> ?p ?o ?g. }

• W2036697637 endingPage "71" @default.
• W2036697637 startingPage "65" @default.
• W2036697637 abstract "Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-chlorotriazine), one of the most widely used herbicides, is classified as a possible human carcinogen by the US Environmental Protection Agency and is a known endocrine disruptor. Recent research has indicated that the estrogenic and antiestrogenic effects elicited by this chemical are not mediated by the estrogen receptor. In this study, we also observed that not only atrazine but also its metabolites did not affect basal or 17β-estradiol induced MCF7-BUS cell proliferation. Therefore, to explain the apparent endocrine disrupting effects of atrazine in vivo, an estrogen-independent mechanism and its metabolites were studied. We examined the alteration in aromatase (CYP19) activity in human choriocarcinoma JEG-3 cells by atrazine and its major metabolites (hydroxyatrazine, diaminochlorotriazine), the conversion of estradiol to hydroxylated metabolites by these compounds associated with cytochrome P4501A. The common metabolite of atrazine, diaminochlorotriazine inhibited the aromatase activity responsible for estrogen synthesis in JEG-3 cells. Atrazine and its metabolites induced 7-ethoxyresorufin-O-deethylase activity and catalyzed estrogen metabolism in MCF-7 cells. These results suggest that the antiestrogenic effects of atrazine may relate to a decrement in estrogen levels caused by aromatase inhibition and estrogen metabolism stimulation by atrazine and its metabolites." @default.
• W2036697637 created "2016-06-24" @default.
• W2036697637 creator A5004864557 @default.
• W2036697637 creator A5025490028 @default.
• W2036697637 creator A5053104393 @default.
• W2036697637 date "2003-01-01" @default.
• W2036697637 modified "2023-09-27" @default.
• W2036697637 title "Antiestrogenic Action of Atrazine and its Major Metabolites in Vitro." @default.
• W2036697637 cites W1577465777 @default.
• W2036697637 cites W1775749144 @default.
• W2036697637 cites W1854566530 @default.
• W2036697637 cites W1968048082 @default.
• W2036697637 cites W1977052923 @default.
• W2036697637 cites W1978841200 @default.
• W2036697637 cites W1989127237 @default.
• W2036697637 cites W1997496944 @default.
• W2036697637 cites W2000448196 @default.
• W2036697637 cites W2006306143 @default.
• W2036697637 cites W2007822731 @default.
• W2036697637 cites W2030716206 @default.
• W2036697637 cites W2037815393 @default.
• W2036697637 cites W2065210744 @default.
• W2036697637 cites W2069690305 @default.
• W2036697637 cites W2073170474 @default.
• W2036697637 cites W2081261434 @default.
• W2036697637 cites W2083675642 @default.
• W2036697637 cites W2089242741 @default.
• W2036697637 cites W2108572185 @default.
• W2036697637 cites W2164943060 @default.
• W2036697637 cites W2396825804 @default.
• W2036697637 cites W4243180786 @default.
• W2036697637 doi "https://doi.org/10.1248/jhs.49.65" @default.
• W2036697637 hasPublicationYear "2003" @default.
• W2036697637 type Work @default.
• W2036697637 sameAs 2036697637 @default.
• W2036697637 citedByCount "19" @default.
• W2036697637 countsByYear W20366976372012 @default.
• W2036697637 countsByYear W20366976372013 @default.
• W2036697637 countsByYear W20366976372014 @default.
• W2036697637 countsByYear W20366976372015 @default.
• W2036697637 countsByYear W20366976372016 @default.
• W2036697637 crossrefType "journal-article" @default.
• W2036697637 hasAuthorship W2036697637A5004864557 @default.
• W2036697637 hasAuthorship W2036697637A5025490028 @default.
• W2036697637 hasAuthorship W2036697637A5053104393 @default.
• W2036697637 hasBestOaLocation W20366976371 @default.
• W2036697637 hasConcept C114246631 @default.
• W2036697637 hasConcept C121608353 @default.
• W2036697637 hasConcept C126322002 @default.
• W2036697637 hasConcept C134018914 @default.
• W2036697637 hasConcept C150903083 @default.
• W2036697637 hasConcept C161176658 @default.
• W2036697637 hasConcept C185592680 @default.
• W2036697637 hasConcept C207001950 @default.
• W2036697637 hasConcept C2776166826 @default.
• W2036697637 hasConcept C2777164284 @default.
• W2036697637 hasConcept C2777477808 @default.
• W2036697637 hasConcept C2779595939 @default.
• W2036697637 hasConcept C2780862370 @default.
• W2036697637 hasConcept C46699223 @default.
• W2036697637 hasConcept C530470458 @default.
• W2036697637 hasConcept C55493867 @default.
• W2036697637 hasConcept C62231903 @default.
• W2036697637 hasConcept C6557445 @default.
• W2036697637 hasConcept C71315377 @default.
• W2036697637 hasConcept C71924100 @default.
• W2036697637 hasConcept C86803240 @default.
• W2036697637 hasConcept C98274493 @default.
• W2036697637 hasConceptScore W2036697637C114246631 @default.
• W2036697637 hasConceptScore W2036697637C121608353 @default.
• W2036697637 hasConceptScore W2036697637C126322002 @default.
• W2036697637 hasConceptScore W2036697637C134018914 @default.
• W2036697637 hasConceptScore W2036697637C150903083 @default.
• W2036697637 hasConceptScore W2036697637C161176658 @default.
• W2036697637 hasConceptScore W2036697637C185592680 @default.
• W2036697637 hasConceptScore W2036697637C207001950 @default.
• W2036697637 hasConceptScore W2036697637C2776166826 @default.
• W2036697637 hasConceptScore W2036697637C2777164284 @default.
• W2036697637 hasConceptScore W2036697637C2777477808 @default.
• W2036697637 hasConceptScore W2036697637C2779595939 @default.
• W2036697637 hasConceptScore W2036697637C2780862370 @default.
• W2036697637 hasConceptScore W2036697637C46699223 @default.
• W2036697637 hasConceptScore W2036697637C530470458 @default.
• W2036697637 hasConceptScore W2036697637C55493867 @default.
• W2036697637 hasConceptScore W2036697637C62231903 @default.
• W2036697637 hasConceptScore W2036697637C6557445 @default.
• W2036697637 hasConceptScore W2036697637C71315377 @default.
• W2036697637 hasConceptScore W2036697637C71924100 @default.
• W2036697637 hasConceptScore W2036697637C86803240 @default.
• W2036697637 hasConceptScore W2036697637C98274493 @default.
• W2036697637 hasIssue "1" @default.
• W2036697637 hasLocation W20366976371 @default.
• W2036697637 hasOpenAccess W2036697637 @default.
• W2036697637 hasPrimaryLocation W20366976371 @default.
• W2036697637 hasRelatedWork W2009015955 @default.
• W2036697637 hasRelatedWork W2045679033 @default.
• W2036697637 hasRelatedWork W2054700953 @default.
• W2036697637 hasRelatedWork W2057515305 @default.

• next