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• W2036698254 abstract "The infectivity associated with prion disease sets it apart from a large group of late-onset neurodegenerative disorders that shares the characteristics of protein aggregation and neurodegeneration. The unconventional infectious agent, PrPSc, is an aberrantly folded form of the normal prion protein (PrPC) and the PrPC-to-PrPSc conversion is a critical pathogenic step in prion disease. Using the Protein Misfolding Cyclic Amplification technique, we converted folded bacterially expressed recombinant PrP into a proteinase K-resistant and aggregated conformation (rPrP-res) in the presence of anionic lipid and RNA molecules. Moreover, high prion infectivity was demonstrated by intracerebral inoculation of rPrP-res into wild-type mice, which caused prion disease with a short incubation period. The establishment of the in vitro recombinant PrP conversion assay makes it feasible for us to explore the molecular basis behind the intriguing properties associated with prion infectivity." @default.
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• W2036698254 date "2011-03-01" @default.
• W2036698254 modified "2023-10-17" @default.
• W2036698254 title "Conversion of bacterially expressed recombinant prion protein" @default.
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• W2036698254 doi "https://doi.org/10.1016/j.ymeth.2010.12.013" @default.
• W2036698254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3049836" @default.
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