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• W2036698732 abstract "Vaccine protection has been achieved in cats against experimental infection with feline immunodeficiency virus (FIV). Such protection has been attributed to FIV-specific humoral immunity, as well as cellular immunity of unknown mechanism(s). Since cell-mediated immunity plays a crucial role in the clearance of viral infections, this study evaluated the role of FIV-specific CTL in vaccine prophylaxis. Cats were immunised with inactivated FIV vaccines, reported to have >90% vaccine efficacy. Significant levels of specific CTL activity were detected following the third immunisation. CTL activity persisted for several months and could be enhanced through a booster immunisation. The levels of CTL activity were comparable to those induced by a recombinant canarypoxvirus based FIV vaccine. These results suggest a possible role for CTL-mediated immunity in vaccine protection against FIV infection in cats." @default.
• W2036698732 created "2016-06-24" @default.
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• W2036698732 date "1997-06-01" @default.
• W2036698732 modified "2023-10-14" @default.
• W2036698732 title "Development of FIV-specific cytolytic T-lymphocyte responses in cats upon immunisation with FIV vaccines" @default.
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• W2036698732 doi "https://doi.org/10.1016/s0378-1135(97)00081-3" @default.
• W2036698732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9231977" @default.
• W2036698732 hasPublicationYear "1997" @default.
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